| 米诺环素对大鼠脑缺血再灌注损伤的脑保护作用 |
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| 引用本文： | 熊建忠,陆兵勋. 米诺环素对大鼠脑缺血再灌注损伤的脑保护作用[J]. 中风与神经疾病杂志, 2010, 27(8) |
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| 作者姓名： | 熊建忠 陆兵勋 |
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| 作者单位： | 1. 萍乡人民医院神经内科,江西,萍乡337000
2. 南方医科大学南方医院神经内科,广东,广州510515 |
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| 摘 要： | 目的探讨米诺环素对局灶性脑缺血再灌注损伤后的脑保护作用。方法 48只SD大鼠随机分为假手术组、生理盐水组、米诺环素治疗组和米诺环素预处理组。采用线栓法制作大脑中动脉缺血再灌注模型。用免疫组织化学法、放射免疫法、Hoechst染色和核磁共振T2WI扫描等方法,观察米诺环素对缺血再灌注大鼠脑组织COX-2、PGE2的表达、细胞凋亡及脑缺血体积的影响。结果米诺环素能降低缺血再灌注大鼠神经细胞凋亡率,减少COX-2、PGE2的表达,缩小脑梗死体积。结论米诺环素对大鼠局灶脑缺血再灌注损伤有脑保护作用。
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| 关 键 词： | 米诺环素 脑缺血再灌注 脑保护 |
The protection of minocycline on the nervous damage induced by focal brain ischemia-reperfusion in rats |
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| XIONG Jian-zhong,LU Bing-xun. The protection of minocycline on the nervous damage induced by focal brain ischemia-reperfusion in rats[J]. Journal of Apoplexy and Nervous Diseases, 2010, 27(8) |
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| Authors: | XIONG Jian-zhong LU Bing-xun |
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| Affiliation: | XIONG Jian-zhong,LU Bing-xun.(Department of Neurology,Nanfang Hospital,Southern Medical University,Guangzhou 510515,China) |
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| Abstract: | Objective To investigate the cerebral protection of minocycline on the focal brain ischemia-reperfusion injury in rats.Methods 48 Sprague-Dawley rats were randomly divided into sham-operation group,control group,minocycline treatment group,and minocycline preconditioning group.Focal cerebral ischemia was produced by introduction of an intraluminal nylon.The expression of cyclooxygenase-2 and prostaglandin E2 was detected with immunohistochemistry and radioimmunity.Hoechst stain was used to observe the neuro... |
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| Keywords: | Minocycline Cerebral ischemia-reperfusion Protection |
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