| 重组人干扰素联合更昔洛韦眼用凝胶治疗单纯疱疹病毒性角膜炎时的外周血T淋巴细胞亚群观察 |
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| 引用本文： | 张晓英.重组人干扰素联合更昔洛韦眼用凝胶治疗单纯疱疹病毒性角膜炎时的外周血T淋巴细胞亚群观察[J].青海医学院学报,2011,32(1):50-52. |
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| 作者姓名： | 张晓英 |
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| 作者单位： | 青海省人民医院眼科 |
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| 摘 要： | 目的探讨重组人干扰素（interferon）联合更昔洛韦眼用凝胶（ganciclovir）对单纯疱疹病毒性角膜炎患者外周血T淋巴细胞亚群的影响。方法对单纯疱疹病毒性角膜炎患者（60例）、健康对照者（30例）应用流式细胞仪测定T细胞亚群并行相关分析。结果单纯疱疹病毒性角膜炎患者治疗前CD3、CD4明显下降（P〈0.05）,CD4/CD8比值下降（P〈0.05）。20例痊愈患者治疗后T淋巴细胞亚群接近正常水平,而10例未痊愈患者虽有所提高,但仍低于健康对照者（P〈0.05）。结论单纯疱疹病毒性角膜炎患者细胞免疫功能降低,干扰素联合更昔洛韦能够增强患者的细胞免疫功能,抑制病毒的复制。
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| 关 键 词： | 单纯疱疹病毒性角膜炎 T淋巴细胞亚群 重组人干扰素 更昔洛韦眼用凝胶 |
THE OBSERVATION OF PERIPHERAL T LYMPHOCYTE SUBGROUP IN RECOMBINANT HUNMAN INTERFERON PLUS GANCICLOVIR OPHTHALMIC GEL TREATING FOR HERPES SIMPLEX KERATITIS |
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| Zhang Xiaoying.THE OBSERVATION OF PERIPHERAL T LYMPHOCYTE SUBGROUP IN RECOMBINANT HUNMAN INTERFERON PLUS GANCICLOVIR OPHTHALMIC GEL TREATING FOR HERPES SIMPLEX KERATITIS[J].Journal of Qinghai Medical College,2011,32(1):50-52. |
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| Authors: | Zhang Xiaoying |
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| Institution: | Zhang Xiaoying(The people's hospital of qinghai province) |
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| Abstract: | Objective To explore the effect of ganciclovir plus interferon on cellular immunity of herpes simplex keratitis(HSK)and the change of T lymphocytes subgroup in peripheral blood.Methods 30 cases of patients HSK and 30 cases of healthy controls were collected.The levels of CD3,CD4,and CD8 were detected by using flow cytometry technology. Results CD3,CD4 as well as CD4/CD8 ratio significantly decreased before treatment in patients with Herpes simplex virus keratitis(P <0.05).20 patients recovered after treatme... |
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| Keywords: | Herpes simplex keratitis T lymphocytes subgroup Recombinant human inferon Ganciclovir eye ophthalmicgel |
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