孕妇HCMV感染及妊娠结局分析

目的了解孕妇感染HCMV后对胚胎、胎儿及妊娠结局的影响.方法采用ELISA方法对4148例长沙地区孕妇进行TORCH-IgM检测.结果在对4148例长沙地区孕妇进行TORCH-IgM检测中,发现有62例孕妇为HCMV-IgM阳性,阳性率为1.5%.在随访的58例孕妇中,妊娠结局为自然流产者达31%(18/58);为死胎及胎儿畸形者达19%(11/58),显著高于其他异常妊娠结局者(P＜0.001).结论HCMV宫内感染是导致胚胎和胎儿自然流产的主要原因之一,同时也是导致胎儿宫内死亡、畸形发生的主要原因.因此,提高孕妇免疫能力,加强孕期健康教育,避免和减少易感因素的接触,是降低胎儿宫内感染的主要措施;另外,大力推广孕前优生检测也是防止胎儿宫内感染发生的重要手段.

Analysis of HCMV infection and pregnant outcome in pregnant woman

Objective: To understand the pregnant finale and embryo or fetal infection of those pregnant women with HCMV infection. Methods: ELISA method was used to test 4148 pregnant women's TORCH infection in Cangha area. Results: Among 4148 tested pregnant women, 62 cases HCMV-IgM positive, positive frequency was 1.5%. 58 cases were proved intrauterine infection with embryo or fetus. In these 58 cases, pregnant finale were: spontaneous abortion 31%(18/58), fetal death and abnormal pregnancy 19%(11/58), significantly higher than other abnormal pregnancy (P<0.001). Conclusion: HCMV intrauterine infection is one of important reasons that may cause spontaneous abortion, fetal death and abnormality. Advanced level of antenatal care and pregnant women's immunity, avoiding and reducing of high risk factor's contacting are main methods to lower intrauterine infection. Furthermore, popularization aristogenesis detect is the important method to prevent fetal infection of TORCH in intrauterine.