硒与肿瘤Ⅰ.使用抑瘤剂量硒时,~(75)Se在艾氏腹水实体瘤小鼠体内的分布

为了对硒抗肿瘤作用途径进行探索,在给稳定性亚硒酸钠2μgSe/g体重的抑瘤剂量时,对接种艾氏腹水实体瘤小鼠的~(75)Se(亚硒酸钠)组织分布进行了观察

SELENIUM AND CANCER I.THE DISTRIBUTION OF 75-SELENIUM IN EHRLICH ASCITES TUMOR BEARING MICE TREATED WITH ANTICARCINOGENIC DOSE OF SELENIUM

In order to explore the role of Se in cancer metabolism, the distribution of 75-Se in mice inoculated Ehrlich ascites tumor (solid form) and treated with an anticarcinogenic dose of stable selenite was investigated. The results showed that the specific activity of each tissue in the groups treated with Se were lower than that without Se. Among all tissues the activity of kidney, liver and blood is comparatively higher and the kidney is the highest. In inoculated tumor but without Se group, the radioactivity of tumor is relatively higher but lower than the kidney, and the ratio of tumor/blood is 3.41. The homogenates of each solid tumor and liver of host -were separated into the nuclei, mitochondria, microsome and soluble subcellular partitions by ultracentrifugation. When the distribution of subcellular partitions were indicated as the percentage of specific activity, no significant differences were fourd between tumor and liver. But the comparism of radioactivity based on mg of tissue protein showed that each subcellular portion of tumor combined more 75-Se than the same portion of livers. Since many mechanisms of anticarcinogenic action are possible of Se, the further studies are in progress