麝香保心丸对冠心病不稳定型心绞痛患者氧化应激的影响

目的:探讨麝香保心丸对冠心病不稳定型心绞痛患者的疗效及对氧化应激的影响.方法:84例冠心病不稳定型心绞痛患者随机分为对照组和观察组各42例.两组均采用常规抗栓和稳定斑块等基础治疗,对照组服用单硝酸异山梨酯片,10 rg/次,3次/d；观察组在此基础上加服麝香保心丸,2粒/次,3次/d.疗程均为8周.若仍有心绞痛发作者,两组均临时含服硝酸甘油片0.5 mg/次.检测治疗前后血清超氧化物歧化酶(SOD)、丙二醛(MDA)、总抗氧化能力(TAC)、脂质过氧化物(LPO)水平,记录心绞痛发作次数、硝酸甘油用量.结果:治疗后观察组总有效率为95.24％,优于对照组的80.95％(P＜0.05)；治疗后观察组平均每天心绞痛发作次数及硝酸甘油用量均明显低于对照组(P＜0.05)；两组治疗后SOD及TAC均较治疗前上升,观察组上升更明显(P＜0.01)；两组治疗后MDA及LPO均较治疗前下降,观察组下降更明显(P＜0.01).结论:麝香保心丸对冠心病不稳定型心绞痛有较好的临床疗效,其作用机制可能与调节心肌细胞的氧化和抗氧化平衡有关.

Influence of Shexiang Baoxin Pills on Oxidative Stress in Patients with Unstable Angina Pectoris of Coronary Heart Disease

Objective: To study the effect of Shexiang Baoxin pills on patients with unstable angina pectoris of coronary heart disease and its influence for the oxidative stress. Method: Eighty-four patients with unstable angina pectoris of coronary heart disease were randomly divided into control group and observation group with 42 cases in each group,the two groups were both treated with basic treatment of conventional antithrombotics and plaque stabilization treatment,the control group were treated with only isosorbide mononitrate tablets,10 mg each time,tid,the observation group were treated with Shexiang Baoxin pills based on the treatment of control group,2 pills each time,tid. The course was 8 weeks. The patients with angina attack were treated with nitroglycerin tablets,0.5 mg each time. The serum superoxide dismutase(SOD),malonaldehyde(MDA),total antioxidant capacity(TAC) and lipid peroxide(LPO)before and after the treatment were detected,and the frequency of angina pectoris and dosage of nitroglycerin were recorded. Result: The total effective rate of observation group after the treatment was 95.24%,and it was higher than 80.95% of the control group(P<0.05),while the frequency of angina pectoris and dosage of nitroglycerin were both lower than those of control group(P<0.05),SOD and TAC of two groups after the treatment were higher than those before the treatment,the increasing of observation group was more obvious(P<0.01),MDA and LPO of two groups after the treatment were lower than those before the treatment,the decreasing in observation group was more obvious(P<0.01). Conclusion: Shexiang Baoxin pills combined with western medicine for treating patients with unstable angina pectoris of coronary heart disease is good,and mechanism of action may be related to the regulation for oxidation and antioxidation balance of myocardial cells.