益气活血化痰方治疗老年颈动脉硬化

目的:观察益气活血化痰方对老年颈动脉硬化患者临床症状、血脂水平及动脉硬化指数(AI)的影响.方法:将58例老年颈动脉硬化患者随机分为治疗组和对照组,在一般治疗基础上,对照组予西洛他唑50 mg每日2次,治疗组在对照组基础上加用中药益气活血化痰方(黄芪、丹参、当归、桑椹、地龙、石菖蒲、茶树根、泽泻、牛膝等组成).治疗并随访12周.治疗前后观察临床症状变化及统计证候积分,检验血脂水平并计算AI值进行对比.结果:经治疗,两组患者临床症状及中医临床证候积分均有改善,以治疗组有效率更高,差异具有统计学意义(P＜0.05)；治疗组血清总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)较对照组降低,高密度脂蛋白胆固醇(HDL-C)较对照组升高,差异具有统计学意义(P＜0.05)；AI较对照组显著降低(P＜0.01).结论:益气活血化痰方可以有效改善老年颈动脉硬化患者临床症状,调节血脂代谢,降低动脉硬化指数,对老年颈动脉硬化患者有益.

Research on Elderly Patients with Carotid Atherosclerosis Treated by Yiqi Huoxue Huatan Fang

Objective: To observe the influence of elderly patients with carotid atherosclerosis treated by and Yiqi Huoxue Huatan Fang on clinical symptoms,lipid levels and arteriosclerosis index. Method: Fifty-eight cases of carotid carotid atherosclerosis patients were randomly divided into treatment group and control group,both groups were given general treatment,gave control group patients Cilostazole 50 mg twice a day,gave treatment group patients Cilostazole 50 mg twice a day and Yiqi Huoxue Huatan Fang (Radix Astragali,Radix Salviae Miltiorrhizae,Radix Angelicae Sinensis,Fructus Mori,Pheretima,Rhizoma Acoritatarinowii,Camellia sinensis, Alisma plantago-aquatica,Achyranthes bidentata etc). After 12 weeks' treatment and follow-up,compared the clinical symptoms changes,statistical syndrome integral,lipid levels and arteriosclerosis index before and after treatment. Result: After treatment,the clinical symptoms and traditional Chinese medicine(TCM) syndrome integral are improved in treatment group compare to control group,the difference is of statistical significance (P<0.05);the treatment group patients' serum total cholesterol(TC),low density lipoprotein cholesterin(LDL-C) are lower than control group,high density lipoprotein cholesterol(HDL-C) level is higher than control group,the differences are of statistical significance (P<0.05).AI is lower than control group, the differences are of statistical significance (P<0.01). Conclusion: Yiqi Huoxue Huatan Fang can effectively improve the elderly patients with carotid atherosclerosis on clinical symptoms,lipid metabolism,reducing the arteriosclerosis index function,have positive effects on elderly patients with carotid atherosclerosis.