艾恒联合氟脲嘧啶/亚叶酸钙治疗晚期胃肠癌32例疗效观察

目的 评价艾恒(OXA)联合亚叶酸钙(LV)、5-氟脲嘧啶(5-FU)方案治疗晚期胃肠癌的疗效。方法 OXA130mg／m^2，静脉滴注2小时，第1天；LV200mg／m^2，静脉滴注2小时后接5-FU400mg／m^2静脉滴注4小时，第1-第5天。每3周重复1次，行2-3周期治疗后判定疗效。结果 32例患者中完全缓解(CR)2例(6．25％)，部分缓解(PR)10例(31．25％)，稳定(NC)9例(28．13％)，进展(PD)11例(34．37％)。总有效率为37．5％。32例中不良反应为3或4度者3例，其中白细胞减少1例，静脉炎1例，肢端感觉异常1例，化疗期间无死亡。结论 艾恒联合亚叶酸钙、5-氟脲嘧啶(OXA-LV／5-FU)方案治疗晚期胃肠癌临床疗效较高，不良反应轻，安全性好。

Oxaliplatin in combination with calcium folinate/5-fluorouracil for advanced gastrointestinal cancer

Objective To evaluate the effects of oxaliplatin in combination with calcium folinate/5 fluorouracil for patients with advanced gastrointestinal cancer. Methods oxaliplatin of 130mg/m2, intravenous drip for 2h, at day 1; calcium folinat of 200mg/m2, intravenous drip for 2 h; followed by 5 fluorouracil of 400mg/m2, intravenous drip for 4h, at day 1-5; were administrated and repeated every 3 weeks. Efficacy was evaluated at 2-3 cycles. Results Thirty-two patients have been entered into the study. Two patients achieved complete remission (6.25%); ten patients, partial remission (31.25%); nine patients unchanged (28.13%); eleven patients aggravated (34.37%). Among the 32 patients, Grade 3 or 4 toxicity occurred in 3 patients including neutropenia in 1 patient,phlebitis in 1 and acroparesthesia in 1. There was no death during the course of treatment. Conclusion Oxaliplatin in combination with calcium folinate/5 fluorouracil is an effective regimen for advanced gastrointestinal cancer with a mild toxicity and high safety.