兔动脉硬化时脑血管血液动力学参数变化及相关性分析

本文报道了兔动脉硬化时，脑血管血液动力学参数（ＣＶＨＰ）的变化。动脉硬化组（ＡＳ组）颈动脉平均血流量（Ｑｍｅａｎ）、平均血流速度（Ｖｍｅａｎ）、最大血流速度（Ｖｍａｘ）、最小血流速度（Ｖｍｉｎ）和脑血管零压顺应性（ＣＯ）显著降低（Ｐ＜０．０５及０．０１），脑血管外周阻力（Ｒ）及脑血管特性阻抗（ＺＣ）显著升高（Ｐ＜０．０５及０．００１）。颈动脉病变程度与Ｑｍｅａｎ、Ｖｍｅａｎ和ＣＯ有显著负相关（Ｐ＜０．０５），与Ｒ和ＺＣ有显著正相关（Ｐ＜０．０５及０．０１）。Ｑｍｅａｎ与Ｖｍｅａｎ、Ｖｍａｘ和ＣＯ有显著正相关（Ｐ＜０．０５及０．０１），与Ｒ和ＺＣ有显著负相关（Ｐ＜０．０１及０．０５）。对照组（Ｃ组）与ＡＳ组回归方程比较，Ｑｍｅａｎ－Ｖｍａｘ和Ｑｍｅａｎ－Ｒ斜率ｂ有显著差别（Ｐ＜０．０１及０．００１）；Ｑｍｅａｎ－Ｖｍｅａｎ、Ｑｍｅａｎ－ＣＯ和Ｑｍｅａｎ－ＺＣ截距ａ有显著差别（Ｐ＜０．０５及０．０１）。

Relational Analysis of the Cerebrovascular Hemodynamic Parameters of the Experimental Arteriosclerotic Rabbit

In the experimental rabbit arteriosclerosis, the changes of the cerebrovascular hemodynamic parameters(CVHP)and their relationships were observed. In arteriosclerosis group (AS group), the mean flow (Qmean), mean velocity (Vmean), maximal velocity (Vmax)and minimal velocity (Vmin) of the carotid blood flow and cerebrovascular compliance for zero pressure(CO)were significantly decreased(P<0. 05,0. 01 ),but the values of cerebrovascular peripheral resistance (R) and the characteristic impedance(Zc) were significantly increased(P<0. 05 and 0. 01) as compared with those in control group(C group). The values of Qmean,Vmean and C0 showed significant negative correlation(P<0. 05,0. 01) but those of R and Zc showed significant positive correlation (P<0. 01 and 0. 05)with the carotid lesions. When compared the linear equations of AS group with those of C group, the regression coefficient b of Qman- Vmax and Qmean-R showed significant difference(P<0. 01 and 0. 001); th e intercept a of Qmean-Vmean, Qmean-CO and Qmean-Zc showed significant difference(P<0 .0 5.0.01).