高血压阳性家族史健康子代血管内皮功能和血清一氧化氮水平分析

目的分析有高血压阳性家族史但血压正常的健康子代,其内皮依赖性血管舒张功能和血清NO水平。方法入选有高血压阳性家族史,但本人血压正常的子代个体48例(男26例,女22例)作为家族史阳性组,取45例血压正常同时无高血压家族史的健康人作为对照组(男24例,女21例),按标准方法测定血压,计算体重指数〔体重指数(BMI)=体重(kg)/身高(m)2〕,抽取空腹静脉血查血糖、总胆固醇、甘油三酯、低密度脂蛋白、高密度脂蛋白、尿酸、肌酐以及血清NO,用无创超声法测定两组血流介导的血管扩张(FMD)和硝酸甘油介导的血管扩张(NMD)。结果与对照组比较,家族史阳性组收缩压和血尿酸水平较高(P<0.05);同时家族史阳性组FMD和血清NO水平均较正常对照组低(P<0.05),而两组间NMD差异无统计学意义。结论有高血压阳性家族史的子代健康个体,即使血压在正常范围时,也已经发生血管内皮依赖性舒张功能降低,血清NO水平下降,对这类人群应早期和严格防治。

Endothelial function and serum nitric oxide level in normotensive offsprings with familial history of hypertension

Objective To stuty the endothelium-dependent vasodilatation and serum nitric oxide(NO) level in normotensive offsprings with familial history of hypertension.Methods Normotensive 48 individuals with familial history of hypertention(positive group) and 45 individuals without familial history of hypertention(control group) were included in the study.The blood pressures were measured,the blood glucose(BS),total cholesterol(TC),triglyceride(TG),high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C),uric acid,serum creatinine and NO were detected.Noninvasive high-resolution ultrasound was used to mesure radial artery diameter at rest,during reactive hyperemia,and after nitroglycerine administration,the flow-mediated dilation(FMD) and nitroglycerine mediated dilation(NMD) were calculated.Results The systolic blood pressure and serum uric acid in the positive group were higher than those in the control group,the FMD decreased in the positive group compared with the contral group,there were no significant differences of NMD in two groups.Conclusion The impaired endothelium-dependent vasodilation and reduction of serum NO level indicate the damage at vessel wall in noimotensive offsprings with familial history of hypertension.