Synthesis and anti-hepatitis B activity of new substituted uracil and thiouracil glycosides |
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| Authors: | Mohammed T. Abdel-Aal |
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| Affiliation: | (1) Department of Medicinal Chemistry, Faculty of Pharmacy, Zagazig University, 44511 Zagazig, Egypt;(2) Rega Institute for Medical Research, Faculty of Medicine, K.U. Leuven, Leuven, Belgium;(3) Environmental Virology Laboratory, Department of Water Pollution, National Research Centre, Dokki, Egypt |
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| Abstract: | A number of N- and S-substituted uracil and thiouracil glycosides were synthesized by coupling reaction of 5,6-dibenzyle pyrimidine derivatives with the corresponding acetobromosugar. The synthesized compounds were tested for their antiviral activity against hepatitis B virus. Plaque reduction infectivity assay was used to determine virus count reduction as a result of treatment with tested compounds which showed moderate to high antiviral activities. |
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