| 端粒酶和CYFRA 21-1对良恶性胸腔积液的鉴别价值 |
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| 引用本文： | 李红梅,于壮,顾华丽,胡晓晓.端粒酶和CYFRA 21-1对良恶性胸腔积液的鉴别价值[J].青岛大学医学院学报,2010,46(4):304-306. |
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| 作者姓名： | 李红梅 于壮 顾华丽 胡晓晓 |
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| 作者单位： | 1. 青岛大学医学院附属医院肿瘤中心,山东,青岛,266003
2. 青岛大学医学院附属医院急症科,山东,青岛,266003 |
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| 基金项目： | 山东省医药卫生科研项目 |
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| 摘 要： | 目的 研究端粒酶和细胞角蛋白19片段(CYFRA 21-1)测定对鉴别良、恶性胸腔积液的价值.方法 采用端粒重复序列扩增-酶联免疫吸附实验法(TRAP-PCR-ELISA)和酶免疫分析法(EIA),分别测定80例恶性胸腔积液和50例良性胸腔积液中的端粒酶活性和CYFRA 21-1水平.结果 胸腔积液中端粒酶活性和CYFRA 21-1的阳性率在恶性胸腔积液组分别为77.5%(62/80)和60.0%(48/80),在良性胸腔积液组分别为6.0%(3/50)和22.0%(11/50),两组比较差异有显著性(χ2=62.921、17.925,P均<0.001).端粒酶活性测定诊断恶性胸腔积液的灵敏度为77.5%(62/80),特异度为94.0%(47/50);CYFRA 21-1诊断的灵敏度60.0% (48/80),特异度78.0%(39/50),两组比较差异有显著性(χ2=4.103、5.316,P<0.05).两者联合检测的灵敏度为90.0%(72/80),特异度为82.0%(41/50),联合检测的灵敏度高于端粒酶和CYFRA 21-1单项检测(χ2=4.592、19.201,P<0.05、0.001).结论 端粒酶和CYFRA 21-1测定对鉴别良恶性胸腔积液均有一定的价值,其中端粒酶测定的灵敏度和特异度较CYFRA 21-1高,两者联合测定可提高诊断准确率.
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| 关 键 词： | 端粒酶 胸腔积液 诊断 鉴别 |
THE VALUE OF TELOMERASE ACTIVITY AND LEVEL OF CYFRA 21-1 IN DIFFERENTIAL DIAGNOSIS BETWEEN BENIGN AND MALIGNANT PLEURAL EFFUSION |
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| LI HONG-MEI,YU ZHUANG,GU HUA-LI,et al.THE VALUE OF TELOMERASE ACTIVITY AND LEVEL OF CYFRA 21-1 IN DIFFERENTIAL DIAGNOSIS BETWEEN BENIGN AND MALIGNANT PLEURAL EFFUSION[J].Acta Academiae Medicinae Qingdao Universitatis,2010,46(4):304-306. |
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| Authors: | LI HONG-MEI YU ZHUANG GU HUA-LI |
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| Institution: | LI HONG-MEI,YU ZHUANG,GU HUA-LI,et al(Tumour Center,The Affiliated Hospital of Qingdao University Medical College,Qingdao 266003,China) |
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| Abstract: | Objective To study the value of telomerase activity(TA) and the level of CYFRA 21-1 in differential diagnosis between benign and malignant pleural effusion. Methods TA and level of CYFRA 21-1 were respectively examined by means of telomeric repeat amplification protocol-PCR-ELISA(TRAP-PCR-ELISA) and EIA from 80 specimens of malignant pleural effusion and 50 benign pleural effusion. Results The positive rates of TA and CYFRA 21-1 were 77.5%(62/80) and 60.0%(48/80),respectively,in specimens of malignant pleur... |
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| Keywords: | CYFRA 21-1 |
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