Distribution of diaphragm blood flow during sevoflurane anaesthesia in dogs |
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| Authors: | Tohru Ide Tetsuo Kochi Kazuhiko Iijima Tadanobu Mizuguchi |
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| Affiliation: | 1. Department of Anesthesiology, School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba-shi, 260, Chiba, Japan
2. Dcpartment of Anesthesiology, National Cancer Hospital East, Chiba, Japan
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| Abstract: | Purpose The purpose of this study was to determine the effect of increasing the concentrations of sévoflurane anaesthesia on the distribution of diaphragm blood flow (Qdi) in ten dogs during mechanical ventilation. Methods Animals were divided into two groups, sévoflurane (n = 6) and time control (n = 4) groups. Blood flow to the crural and the costal diaphragm (Qcru, Qcost) was determined by the hydrogen clearance technique at 0, 0.5, 1.0 and 1.5 minimum alveolar concentration (MAC) of sévoflurane after a 30 min period of steady-state conditions. Cardiac output (CO) and the mean arterial blood pressure (MBP) were also measured. Results Sevoflurane anaesthesia caused a reduction in CO (L · min?1) from a control value of 1.51 ± 0.21 to 1.38 ±0.1 (0.5 MAC), 1.09 ± 0.15 (1.0 MAC) and 0.98 ± 0.12 (1.5 MAC) (Mean ± SD). Mean blood pressure, Qcru and Qcost also decreased with increasing depth of anaesthesia. In addition, the decrease of Qcru was greater than that of Qcost at all levels of MBP and CO. No change occurred in these variables in the lime control group. Conclusion Sevoflurane anaesthesia changes the distribution of Qdi with a greater reduction occurring in Qcru than in Qcost. |
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