| 血管内皮生长因子与缺氧缺血性脑损伤的研究进展 |
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| 引用本文： | 宋健文,谢红,刘俐. 血管内皮生长因子与缺氧缺血性脑损伤的研究进展[J]. 中国妇幼健康研究, 2003, 14(3): 168-170 |
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| 作者姓名： | 宋健文 谢红 刘俐 |
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| 作者单位： | 西安交通大学第一医院,陕西,西安,710061;四川省中医研究院附属医院儿科,610041 |
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| 摘 要： | 缺氧缺血性脑损伤的发病机制目前尚未完全明确 ,缺氧时血管内皮生长因子有不同程度的表达 ,其在缺氧缺血后的脑组织中的表达特点与多种因子及mRNA的水平有关 ,血管内皮生长因子具有促进内皮细胞增殖 ,增加新生血管生成 ,改变血管通透性等功能 ,它在缺氧缺血性脑损伤发病及转归中具有不容忽视的作用
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| 关 键 词： | 血管内皮生长因子 缺氧缺血性脑损伤 |
| 文章编号： | 1008-2514(2003)03-0168-03 |
| 修稿时间： | 2003-03-05 |
Progress in study on the correlation of vascular endothelial growth factor with hypoxic-ischemic brain damage |
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| Song Jianwen,Xie Hong,Liu Li//. Progress in study on the correlation of vascular endothelial growth factor with hypoxic-ischemic brain damage[J]. Chinese Journal of Maternal and Child Health Research, 2003, 14(3): 168-170 |
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| Authors: | Song Jianwen Xie Hong Liu Li// |
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| Affiliation: | Song Jianwen,Xie Hong,Liu Li//Department of Pediatrics,The First Hospital of Xi'an Jiaotong University,Shaanxi Xi'an 710061,China. |
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| Abstract: | At present, the mechanism on hypoxic ischemic brain damage(HIBD) is not completely clear. In hypoxia, vascular endothelial growth factor (VEGF) is expressed at varying degree and the expression of VEGF in hypoxic and ischemic brain tissue is associated with various kinds of cellular factors and the level of mRNA. VEGF is a potent vascular endothelial cell inducer which can promote the proliferation of endothelial cell, resulting in hypervascularization and change in permeability of the blood vessel. VEGF plays an important role in the development and prognosis of HIBD. |
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| Keywords: | hypoxic ischemic brain damage vascular endothelial growth factor |
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