| G蛋白参与C1q／C1qR系统介导的信号转导 |
| |
| 引用本文： | 陈政良 谢佩蓉. G蛋白参与C1q／C1qR系统介导的信号转导[J]. 免疫学杂志, 1996, 12(2): 91-95 |
| |
| 作者姓名： | 陈政良 谢佩蓉 |
| |
| 作者单位： | 第三军医大学免疫学教研室，第一军医大学免疫学教研室 |
| |
| 基金项目： | 全军“八五”医药卫生科研基金 |
| |
| 摘 要： | ａｇｇ－Ｃ１ｑ可抑制人Ｔ细胞系Ｊｕｒｋａｔ和Ｍψ系Ｕ９３７细胞受霍乱毒素刺激的（ｃＡＭＰ）ｉ增高，而百日咳毒素能遏止人Ｂ细胞系Ｒａｊｉ细胞ａｇｇ－Ｃ１ｑ诱导的（ｃＡＭＰ）ｉ升高和Ｃ１ｑＲ交联所促成的磷脂酰肌醇水解。表明：Ｇ蛋白介入了Ｃ１ｑ／Ｃ１ｑＲ系统介导的信号转导途径。
|
| 关 键 词： | G蛋白 C1q／C1qR系统 免疫细胞 |
Role of G proteins in signal transduction through C1qR in human immune cells |
| |
| Chen Zhengliang,Xie Peirong. Role of G proteins in signal transduction through C1qR in human immune cells[J]. Immunological Journal, 1996, 12(2): 91-95 |
| |
| Authors: | Chen Zhengliang Xie Peirong |
| |
| Abstract: | We investigated the role of G proteins in the signal transduction pathways mediated by C1q receptor(C1qR)in human T lymphocyte line Jurkat,B lymphocyte line raji and macrophage line U937 and made the following findings:interaction of aggregated C1q(agg-C1q)with C1qR inhibited the increase in the level of cAMP in Jurkat and U937 cells stimulated by cholera toxin while pertussis toxin depressed the raise in the concentration of cAMP induced by agg-C1q and the phosphatidylinositol hydrolysis facilitated by cross-linking of C1q receptors in Raji cells. |
| |
| Keywords: | G proteins Signal transduction C1q/C1qR system Immune cells |
| 本文献已被 CNKI 维普 等数据库收录！ |
