慢性乙肝患者杀伤性免疫细胞功能的研究

通过对４４例病毒性肝炎患者Ｔ细胞亚群，ＮＫ细胞活性与ＬＡＫ细胞活性的观察，探讨了在慢性乙型肝炎病毒复制与非复制状态下的杀伤性细胞活性。结果表明：在乙肝病毒的高复制状态下，ＣＤ８＾＋细胞数增加，ＣＤ４＾＋／ＣＤ８＾＋比例显著下降；ＮＫ细胞活性与ＬＡＫ细胞活性也明显低下，且在ＨＢｅＡｇ与ＨＢＶＤＮＡ阳性组中，ＮＫ活性与ＬＡＫ活性的改变与ＨＢｅＡｇ的Ｐ／Ｎ值变化呈显著负相关，而ＮＫ活性与ＬＡＫ活性变化则

Study on the relationship between the cytotoxicity of killer cells and replication of virus in patients with chronic hepatitis B

In order to investigate the cytotoxicity of killer cells in replication and non-replication conditions of chronic HBV infection, we determined the percentage of blood T cell subsets,natural killer(NK)activity,and lymphokine-activated killer(LAK) activity in 44 patients with viral hepatitis. The results showed that in high viral replication group,the percentage of CD T cells was increased and the ratio of CD4/CD8, NK and LAK activity were significantly decreased.The NK activity and LAK activity were inversely correlated with P/N value of HBeAg in HBeAg and HBV DNA positive group, positive correlation was also found between NK and LAK activity in this group. In addition,we had also observed that in chronic persistent hepatitis,the percentage of CD T cells were higher than that of chronic active hepatitis and NK, LAK activity were lower than CAH.These results suggested that the cytotoxicity of the killer cells has an important role in immune responses against HBV infection.