检测循环肿瘤细胞(CTC)在临床肿瘤诊断和治疗中的作用

有关循环肿瘤细胞的理论已有很长时间。肿瘤转移及复发的过程均是一个循环肿瘤细胞定植生长的级连放大的瀑布反应。目前肿瘤的发现和诊断仍高度依赖于影像学及肿瘤特异性血清标志物的方法,不能及时发现肿瘤的转移和复发。基于肿瘤细胞播散理论,检测循环肿瘤细胞可更早期有效发现肿瘤的早期转移和复发。本文对文献报道的检测循环肿瘤细胞在临床肿瘤诊断和治疗中的作用进行了总结,并与目前经典的标志物和影像学进行了比较。

The role of detecting circulating tumor cell (CTC) in clinical cancer diagnosis and therapeutics

The concept of existence of circulating tumor cells(CTCs)has a history of over 100 years.The metastasis and recurrence progress of the solid tumor are highly associated with the circulating tumor cell invade cascade.Nowadays the screening and diagnosis of solid tumor mainly depend on the classical radiology and tumor specific serum marker.Based on the CTC theory,detecting circulating tumor cell would help the clinician finding early metastasis or recurrence more effectively.We undertook a review of the published literature on this topic.Also we compare the three tumor-detecting methods in this paper.