Cyclin E在乳腺癌组织中的表达及其与乳腺癌预后的关系 |
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引用本文: | 何文山,黄韬,王海久.Cyclin E在乳腺癌组织中的表达及其与乳腺癌预后的关系[J].华中科技大学学报(医学版),2004,33(3):304-307. |
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作者姓名: | 何文山 黄韬 王海久 |
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作者单位: | 华中科技大学同济医学院附属协和医院普通外科,武汉,430022 |
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基金项目: | 卫生部优秀青年人才科研基金资助项目(No.97028) |
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摘 要: | 目的 通过研究细胞周期蛋白E (cyclinE)在乳腺癌组织中的表达 ,探求cyclinE判断乳腺癌预后的潜在价值。方法 用免疫组织化学的方法检测 80例乳腺癌以及 18例良性乳腺肿瘤患者的病理组织切片标本上cyclinE、HER 2 /neu、nm2 3 H1、肌动蛋白 (actin)的表达 ,分析cyclinE与患者临床资料、HER 2 /neu、nm2 3 H1,actin间的关系。结果 CyclinE的表达率 :乳腺癌明显高于良性乳腺肿瘤 (P <0 0 1) ;乳腺癌晚期高于早期 (P <0 0 5 ) ;雌激素受体 (ER)阳性者明显低于ER阴性者 (P <0 0 5 ) ;孕激素受体 (PR)阳性者与阴性者无明显差异 (P >0 0 5 ) ;HER 2 /neu阳性者高于阴性者 (P <0 0 5 ) ,ER、PR、HER 2 /neu均阳性者表达率更高 (P <0 0 1) ;在nm2 3 H1阴性和阳性者中 ,表达无显著性差异 (P >0 0 5 ) ;在actin阳性且呈连续分布者中明显低于actin阴性或不连续分布者(P <0 0 5 )。结论 CyclinE的表达水平同乳腺癌患者的预后有着密切的关系。
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关 键 词: | 细胞周期蛋白E 乳腺肿瘤 预后 |
修稿时间: | 2004年1月6日 |
The Expression of Cyclin E and Its Relationship with the Prognosis in Patients with Breast Cancer |
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Abstract: | Objective To investigate the expression of cyclin E, so as to find out the potential of cyclin E as a biomarker evaluating the prognosis of breast cancer.Methods The expression of cyclin E, HER-2/neu, nm23-H1 and actin was detected in 80 breast cancer tissues and 18 benign breast tumor tissues by immunohistochemical methods. The relationship between cyclin E and the remaining genes or the clinical data of the patients with breast cancer was analyzed. Results The overexpression rate of cyclin E in malignant tissues was obviously higher than that in benign tumor tissues (P<0.01). The overexpression of cyclin E in later stage of disease was higher than that in early stage of disease (P<0.05). The expression of cyclin E in ER positive tissues was lower than that in ER negative tissues (P<0.05). The expression of cyclin E in PR positive tissues and in PR negative tissues showed no significant difference (P>0.05). The expression of cyclin E in HER-2/neu positive tissues was higher than that in HER-2/neu negative tissues (P<0.05). And the expression of cyclin E in ER, PR and HER-2/neu all positive tissues was much higher, P<0.01. The expression of cyclin E in nm23-H1 positive tissues and in nm23-H1 negative tissues showed no significant difference, P>0.05. The expression of cyclin E in actin positive and continuous distribution tissues was lower than that in actin negative or un-continuous distribution tissues, P<0.05. Conclusion The expression of cyclin E has a strong correlation to the prognosis of breast cancer. |
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Keywords: | cyclin E breast tumor prognosis |
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