92例子宫内膜癌的临床特点及预后影响因素分析

目的 探讨子宫内膜癌的临床特点及与预后的相关性,为临床治疗提供依据.方法 回顾性分析手术初治的92例子宫内膜癌患者的临床资料,随访观察5年生存率,并对可能影响预后的临床指标进行单因素和多因素分析.结果 92例患者5年生存率为72.41%.单因素分析显示,病理类型、病理学分期、组织学分级、肌层浸润、宫颈受累、盆腔淋巴结转移与生存时间有显著相关性(P＜0.05).多因素回归分析表明,影响子宫内膜癌患者生存时间的独立预后因素为病理类型、组织学分级和肌层浸润.结论 病理类型、组织学分级和肌层浸润为影响子宫内膜癌患者生存时间的独立预后因素,据此制定规范化个体治疗方案有望提高患者的生存率.

Abstract：

Objective To study the dependablity of clinical characteristics and prognosis in patients with endometrial cancer,so as to apply the basis for the treatment. Methods The clinical and pathological data of 92 patients with endometrial cancer were analyzed retrospectively, 5-year survival rate was followed and observed. Using Cox proportional hazard regression analysis to evaluate the factors related to overall survival. Results The overall 5-year survival rate was 72.41%. Using univariate analysis, the survival time was correlated with histologic type, pathological staging, histologic grade, myometrium invasion,cervical invasion and lymph node metastasis (P＜0.05).Using multivariate analysis, the survival time was correlated with histologic type,histologic grade and myometrium invasion. Conclusions Histologic type, histologic grade and myometrium invasion are independent prognostic factors for survival time of patients. In order to improve the prognosis of the patients, they should be treated by individual therapies.

Analysis of clinical characteristics and prognostic factors in 92 cases of endometrial cancers

Objective To study the dependablity of clinical characteristics and prognosis in patients with endometrial cancer,so as to apply the basis for the treatment. Methods The clinical and pathological data of 92 patients with endometrial cancer were analyzed retrospectively, 5-year survival rate was followed and observed. Using Cox proportional hazard regression analysis to evaluate the factors related to overall survival. Results The overall 5-year survival rate was 72.41%. Using univariate analysis, the survival time was correlated with histologic type, pathological staging, histologic grade, myometrium invasion,cervical invasion and lymph node metastasis (P＜0.05).Using multivariate analysis, the survival time was correlated with histologic type,histologic grade and myometrium invasion. Conclusions Histologic type, histologic grade and myometrium invasion are independent prognostic factors for survival time of patients. In order to improve the prognosis of the patients, they should be treated by individual therapies.