甲状腺冷结节^99mTc-MIBI显像诊断甲状腺癌的Meta分析

[目的]通过Meta分析综合评价甲状腺冷结节^99mTc-MIBI显像诊断甲状腺癌的价值，并比较观察法与定量，半定量法的准确性。[方法]检索万方、维普、中国知网CNKI数据库中研究甲状腺冷结节^99mTc-MIBI显像诊断甲状腺癌的文献，按照循证医学诊断性试验的标准筛选文献。用MetaDisc1．4软件合并纳入的试验结果，并绘制SROC曲线。[结果]观察法组纳入病例数为803例，合并灵敏度、特异度及加权SROC曲线下面积（AUC）分别为83．2％、78．2％、0．8904，定量／半定量法组纳入病例数为471例，上述各值分别为81．6％、90．0％、0．9273。[结论]甲状腺冷结节^99mTc-MIBI显像对甲状腺癌的诊断具有较高价值。观察法和定量／半定量法灵敏度相接近，后者的特异度高，对甲状腺癌的诊断准确性更高。

Meta Analysis on 99m Tc-MIBI Scintigraphy of Cold Thyroid Nodule in Diagnosis for Thyroid Cancer

[Purpose] To assess the value of the cold thyroid nodule ^99mTc-MIBI scintigraphy in diagnosing thyroid cancer by Meta-analysis, and to compare the diagnostic accuracy of observation method （OM） and quantitative/semiquantitative method （QSM）. [Method] Wanfang,Vip and CNKI database were searched for literatures related to the cold thyroid nodule ^99mTc-MIBI scintigraphy in diagnosing thyroid cancer. The literatures were assessed and screened according to the standards for diagnostic test of evidence-based medicine. Data were pooled and summary receiver operating characteristic （SROC） curve was drawn by MetaDisc1.4 software. [Result] Of the 803 cases in OM group, the pooled sensitivity, specificity and the AUC of weighted summary receiver operating characteristic （SROC） curve were 83.2%, 78.2% and 0.8904 respectively. Of the 471 cases in QSM group those were 81.6%, 90.0% and 0.9273 respectively. [Conclusion] The cold thyroid nodule ^99mTc-MIBI scintigraphy plays a role in diagnosing thyroid cancer. OM and QSM have similar sensitivity. The later has higher specificity and accuracy in diagnosing thyroid cancer.