Role of the CDC8 gene in the repair of single strand breaks in DNA of the yeast Saccharomyces cerevisiae |
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Authors: | H Baranowska D Zaborowska W J Jachymczyk J ?uk |
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Institution: | (1) Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Rakowiecka 36, PL-02-532 Warsaw, Poland |
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Abstract: | Summary It has been found that the repair of single strand breaks is defective in the DNA replication mutants cdc8-1 and cdc8-3 of Saccharomyces cerevisiae both in permissive (23°C) and restrictive conditions (36°C). In permissive conditions we observed a significant delay in single strand break repair in a diploid strain HB7 (cdc8-1/cdc8-1), as compared with the wild-type strain. Under restrictive conditions no repair was observed, but rather degradation of MMS-damaged DNA occurred. It has been also found that the repair of single strand breaks in yeast is inhibited by cycloheximide but not by hydroxyurea. |
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Keywords: | CDC8 gene DNA repair |
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