腰椎间盘突出症蛋白质组学变化与中医证型的相关性

背景：腰椎间盘突出症的中西医结合治疗效果较好。目的：全面综述腰椎间盘突出症中医辨证分型与蛋白质组学相关的研究。方法：检索万方、清华同方等中文数据库及Pubmed数据库2001-01/2010-12的相关文章,中文检索词为＂中医证型、蛋白质组学、腰椎间盘突出症＂,英文检索词为＂syndrome types,traditional Chinese medicine,protcomics,lumbar intervertebral disk protrusion＂。纳入腰椎间盘突出症血清蛋白质组学研究及蛋白质组学、中医分型与中医药3者关联的研究,排除重复研究及Meta分析类文章。结果与结论：计算机检索得到361篇文献,中文79篇,英文282篇,阅读标题与摘要进行筛选,排除与此文无关的文献。对29个符合要求的研究进行综述。研究认为,部分疾病的中医分型与血清蛋白质组学有关,机体某些特异性标志蛋白表达可能与椎间盘退变相关。腰椎间盘突出症与中医血瘀证、湿热证、寒湿证等证型的关联性得到了部分实验及临床的验证,但缺乏蛋白质组学相关性研究。

Relationship between proteomic changes and traditional Chinese medicine syndrome type of lumbar intervertebral disc protrusion

BACKGROUND：It is reported in lots of literature that integrated traditional Chinese medicine and western medicine therapy has better effect on lumbar intervertebral disc protrusion,however,the etiology and pathogenesis of the disease remains elusive.OBJECTIVE：Although some domestic and foreign scholars have carried out preliminary researches on the proteomics features of syndrome types in traditional Chinese medicine（TCM）,the proteomics of syndrome type of lumbar intervertebral disc has not been reported so far.METHODS：A literature search was performed in Wanfang data,Tshinghua and Medline databases for the relevant research articles published from January 2001 to November 2010 using ＂syndrome type,traditional Chinese medicine（TCM）,protcomics,lumbar intervertebral disk protrusion＂ in Chinese and English.Inclusion criteria：（1） papers on serum protcomics of lumbar intervertebral disc protrusion.（2） Papers on association of proteomics,the syndrome types and TCM.Exclusive criteria：papers with repetitive contents and meta analysis.RESULTS AND CONCLUSION：27 research articles that met the inclusive criteria were selected out of 361 research articles（79 in Chinese,282 in English） by excluding the irrelevant papers according to their titles and abstracts.We conclude that the TCM syndrome types of some diseases relate to serum proteomics and the expression of some specific marker proteins may be associated with disc degeneration.Although the association between lumbar intervertebral disk protrusion and some syndrome types（blood stasis syndrome,damp-heat syndrome and cold-damp syndrome） has been validated by some experiments and clinical practice,there is still a lack of research on the relationship between proteomics and lumbar intervertebral disk protrusion.