基于动态增强磁共振测定大鼠股骨近端骨髓血流灌注功能及稳定性

背景：随着磁共振成像线圈的改进和新对比剂的使用,利用动态增强磁共振测定大鼠骨髓血流灌注功能已成为可能。目的：建立基于动态增强磁共振测定大鼠股骨近端骨髓血流灌注功能的方法,并观察其稳定性。方法：Wistar大鼠尾静脉注射对比剂,基于动态增强磁共振,利用1.5T全身磁共振系统采集股骨近端骨髓的时间-信号强度数据。1周后重复测量1次。通过时间-信号强度曲线计算最大增强率和增强系数。结果与结论：前后两次测量的最大增强率分别为（140.42±17.17）%和（136.57±13.87）%,增强系数分别为（3.81±0.17）%/s和（3.71±0.20）%/s,两次检测的最大增强率和增强系数差异无显著性意义。说明基于动态增强磁共振的大鼠股骨近端骨髓血流灌注功能测定方法稳定可靠。

Perfusion function of rat proximal femur bone marrow and its stability determined using dynamic contrast-enhanced MRI

BACKGROUND：Due to improvement of MRI surface coil and new-type contrasts,it is possible to use dynamic contrast-enhanced MRI to measure bone marrow blood perfusion function in rats.OBJECTIVE：To explore the methodology using dynamic contrast-enhanced MRI to measure the perfusion function of rat proximal femur bone marrow and explore its reliability.METHODS：Contrast agents were injected from tail vein into Wistar rats.Dynamic contrast-enhanced MRI was measured using 1.5T whole body MRI scanner.One week later,the measurement was repeated.Then,time-signal intensity curve was explored.Maximum enhancement（ME） and enhancement slope（ES） were calculated.RESULTS AND CONCLUSION：ME of test 1 and test 2 were（140.42±17.17）% and（136.57±13.87）%,respectively.ES of test 1 and test 2 were（3.81±0.17）%/s and（3.71±0.20）%/sec,respectively.There was no statistically significant difference in ME and ES between the two tests.The methodology explored in this study which used dynamic contrast enhanced MRI to measure the perfusion function of rat proximal femur bone marrow were reliable and repeatable.