去神经支配骨骼肌萎缩的多种治疗

背景：骨骼肌去神经支配后出现肌萎缩和收缩功能的丧失,肌纤维发生与萎缩相关的一系列的形态学和组织学的变化。近年来随着技术水平及理论研究的进展,治疗效果有了较大的提高,但仍未达到满意的效果。目的：总结并讨论近年来有关去神经支配骨骼肌萎缩的治疗新进展,为肌肉功能的恢复提供理论基础。方法：由第一作者用计算机检索中国期刊全文数据库（CNKI：2000/2010）和Medline数据库（2000/2010）,检索词分别为＂去神经支配,骨骼肌,肌萎缩,治疗＂和＂denervated,skeletal muscles,atrophy,treatment＂。共检索到135篇文章,按纳入和排除标准对文献进行筛选,共纳入30篇文章,从物理治疗、神经修复和植入、细胞移植、药物、基因和中药治疗等方面进行总结和分析。结果与结论：近年来去神经支配骨骼肌的治疗取得了很大进展,但这些方法只能在一定程度上缓解骨骼肌萎缩,在一段时间内维持肌肉的生理功能。目前研究随着去神经支配骨骼肌萎缩机制的阐明,针对性的治疗措施将会取得更好的效果。

Multiple treatments for denervated skeletal muscle atrophy

BACKGROUND：Following denervation, the loss of contractile function and amyotrophy occur in skeletal muscle, and myofibers show a series of histomorphological changes concerning amyotrophy. With progress in technical levels and theory research, considerable improvement in the treatment effects have been achieved, but it is not satisfactory. OBJECTIVE：To summarize and discuss the recent progress in treatment methods of denervated skeletal muscles atrophy and provide theoretical evidence for recovery of muscle function. METHODS：A computer-based retrieval was performed by the first author in the CNKI and Medline databases to search papers published between 2000 and 2010 using key words ＂denervated, skeletal muscles, atrophy, treatment＂ in Chinese and English languages. A total of 135 papers were retrieved. According to inclusion and exclusion criteria, 30 papers were included in the final analysis. These included papers were summarized and analyzed from the aspects of physiotherapy, nerve repair and implantation, cell transplantation, drug, gene and traditional Chinese medicine treatment.RESULTS AND CONCLUSION：Great progress has been recently made in treatment of denervated skeletal muscles. However, the methods used can only alleviate skeletal muscle atrophy to an extent and maintain muscular physiological function for a time period. The mechanism underlying denervated skeletal muscle atrophy has been clarified and the corresponding measures would acquire better therapeutic effects.