喷墨打印技术同步打印细胞和生物支架材料及在组织工程中的应用

背景：喷墨打印技术是将墨滴喷射到接受体形成图像或文字的非接触性打印技术。目的：总结并讨论喷墨打印技术的研究进展及其在组织工程中的运用。方法：由第一作者用计算机检索中国期刊全文数据库（CNKI：1995/2010）和PubMed数据库（1995/2010）,检索词分别为＂喷墨打印技术,细胞打印,生物材料,细胞因子＂和＂inkjetprinting,cellprinting,biomaterial,cytokine,organprinting＂。共检索到352篇文章,按纳入和排除标准对文献进行筛选,共纳入35篇文章。从喷墨打印技术研究进展及其在组织工程中的运用2个方面进行总结,对喷墨打印技术在细胞打印、生物支架材料打印、细胞活性因子打印及细胞-生物支架材料同步打印的应用等方面进行介绍。结果和结论：喷墨打印技术作为一种新型组织工程技术,在组织与器官打印研究中有广泛的运用前景。该技术可以打印多种细胞,打印后的细胞能够存活和保持原有生物学活性,而且喷墨打印技术通过打印水凝胶支架材料,构建具有良好的三维结构的3D水凝胶支架。此外,运用喷墨打印技术可以打印细胞活性因子,并保持其生物学活性。通过同步打印细胞和生物支架材料,喷墨打印技术有望构建3D细胞-生物支架材料复合的仿生组织和器官。

Application of inkjet printing to simultaneous printing of biomaterials and cells and tissue engineering

BACKGROUND： Inkjet printing is a non-contact reprographic technique that reproduces image or character onto a substrate using ink drops. OBJECTIVE： To sum and discuss the advances in inkjet printing technology and the application of inkjet printing technology in tissue engineering. METHODS： The first author searched relevant literatures from CNKI （1995/2010） and PubMed （1995/2010）. The Keywords were ＂inkjet printing, cell printing, biomaterial, cytokine, organ printing＂ in Chinese or English. Totally 352 articles were retrieved, and finally 35 articles were included in result analysis. This paper summarizes and previews the application of inkjet printing technology in tissue engineering, including cell printing, biomaterials printing, cytokine printing, simultaneous printing of biomaterials and cells. RESULTS AND CONCLUSION： Inkjet printing technology, which is used to print a variety of cells, can survive and maintain cell biological activity, construct good three-dimensional structure of the three-dimensional hydrogel scaffold by printing hydrogel, and print cytokines and maintain its biological activity; the inkjet printing technology is expected to construct three-dimensional cells-biological bio-mimetic composition through synchronous printing cells and biological materials.