自体骨髓干细胞治疗肝硬化基础研究与临床应用现状

背景：活体肝移植仍面临很多问题：如供体的匮乏、移植后的免疫排异反应及其高额的费用等,因此使其在临床上的开展受到限制。目的：说明自体骨髓干细胞移植可以分化成熟肝细胞而替代受损的肝脏组织发挥功能,从而改善患者症状,提高患者生活质量。方法：利用计算机在PubMed、CNKI、万方数据库和维普数据库中检索2000-01/2010-12关于自体骨髓干细胞移植相关文章,在标题和摘要中用＂骨髓干细胞;自体骨髓干细胞移植;肝硬化＂或＂Bone marrow stem cell,autologous bone marrow stem cell,hepatic cirrhosis＂为检索词进行检索。选择与骨髓干细胞移植相关的文章内容,同一领域文献选择近期发表或发表在权威杂志文章。初检得到235篇文献,根据纳入标准选择20篇文章进行综述。结果与结论：通过对自体骨髓干细胞移植从基础研究及临床研究方面的最新进展的了解,说明自体骨髓干细胞移植在对肝硬化的治疗方面前景广阔。

Basic and clinical research of autologous bone marrow stem cells in treatment of hepatic cirrhosis

BACKGROUND：Liver transplantation is still facing many problems,such as lack of donor livers,immune rejection after transplantation and its high costs,thus making it restricted in clinic application.OBJECTIVE：To describe autologous bone marrow stem cell transplantation in the clinical stage as one of the most promising technology that autologous bone marrow stem cells can differentiate into mature liver cells to replace the damaged liver functioning,which can improve symptoms and quality of life in patients.METHODS：A computer-based online search of PubMed database,CNKI,Wanfang database and VIP database was performed for articles regarding autologous bone marrow stem cells to treat hepatic cirrhosis,with the key words of ＂bone marrow stem cell,autologous bone marrow stem cell transplantation,hepatic cirrhosis＂ in Chinese and ＂bone marrow stem cell,autologous bone marrow stem cell,hepatic cirrhosis＂ in English.Relevant articles published in recent years or in authorized journals were preferred.Repetitive studies were excluded.Finally,20 articles were included.RESULTS AND CONCLUSION：Basic and clinical research about autologous bone marrow stem cell transplantation indicate that autologous bone marrow stem cell transplantation has a broad prospect in the treatment of hepatic cirrhosis.