水疗与电刺激联合防治大鼠失用性骨质疏松

背景：电刺激和水疗均对失用性骨质疏松有治疗作用,二者联合应用未见报道。目的：观察水疗与电刺激联合作用对失用性骨质疏松模型大鼠生物力学的影响。方法：采用切断坐骨神经和股神经的方法制备SD大鼠失用性骨质疏松模型。伤口愈合后采用电刺激、水疗及二者联合干预8周,观察大鼠体质量及股骨生物力学指标的变化。结果与结论：去神经后失用性骨质疏松大鼠体质量显著增加,股骨的材料力学和结构力学指标上均出现明显异常,经电刺激和（或）水疗干预后失用性骨质疏松大鼠的体质量有所下降,股骨的材料力学和结构力学指标有所改善,尤其是电刺激和水疗联合应用,可明显改善失用性骨质疏松大鼠股骨的最大载荷、破断载荷、弹性模量和极限强度。

Balneotherapy combined with electrical stimulation for treatment of disuse osteoporosis

BACKGROUND：Both electrical stimulation and balneotherapy exhibit therapeutic effects on disuse osteoporosis.The combined application of these two methods has been rarely reported.OBJECTIVE：To investigate the effects of electrical stimulation combined with balneotherapy on biomechanics of rat models of disuse osteoporosis.METHODS：Sprague-Dawley rat models of disuse osteoporosis were developed by resection of sciatic nerve and femoral nerve.After wound healing,rats were interfered for 8 weeks with electrical stimulation,balneotherapy or their combination.Rat body weight and femoral biomechanics were investigated.RESULTS AND CONCLUSION：After denervation,body mass of rats with disuse osteoporosis was greatly increased,the femur exhibited obvious abnormality in material and structural mechanics.After electrical stimulation and（or）balneotherapy,body mass of rats with disuse osteoporosis was decreased,and the material and structural mechanics were improved.In particular after electrical stimulation combined with balneotherapy,the maximum load,breaking load,elastic modulus,and ultimate strength of the femur of rats with disuse osteoporosis were obviously improved.