纳米银生物安全性及其在树脂基托中的应用

背景：近年来纳米银已在医学生物学领域得到了广泛应用,它具有很稳定的物理化学性能,且广谱抗菌,效力持久,无耐药性。随着越来越多的纳米银产品被研制出来,对它的生物安全性研究也逐渐引起人们的关注。目的：围绕纳米银的生物安全性研究现状作以综述,并初步分析其在树脂基托中的抗菌作用及对基托性能的影响。方法：于2000/2010应用计算机检索CNKI数据库、PUDMED数据库,OVID数据库中有关银系无机抗菌剂及其在基托树脂中的应用等相关文章,挑选出有代表性的30篇中英文文献做进一步分析。结果与结论：讨论纳米银生物安全性这个问题时,要从形态,尺寸粒径,剂量等方面综合考虑,不能简单的说是有毒的还是无毒的。此外,纳米银对口腔常见致病菌如变形链球菌、乳杆菌、白色念珠菌有较强杀菌作用,将其应用到树脂基托中可以预防和治疗义齿性口炎,但如何克服基托氧化变色等问题仍有待进一步研究。

Biological security of silver nanoparticles and their use in denture base resin

BACKGROUND：In recent years,silver nanoparticles have been widely used in medicinal and biological fields. What is more,silver nanoparticle antibacterial agents have a wide antimicrobial spectrum,long lasting effect,non-drug tolerance as well as the fine physical-chemistry properties. As more and more nano-silver products have been developed,their bio-safety researches have gradually attracted people＇s attention. OBJECTIVE：To review the biological security of silver nanoparticles,and to preliminarily analyze its antibacterial effect in the denture resin base as well as the influence on the properties of the resin. METHODS：A computer based retrieve of the articles related to silver-based inorganic antimicrobial agent and its application in the denture base resin was performed in CNKI,PubMed and OVID databases during 2000 to 2010. Finally,30 representative literatures in Chinese and English was included for further analysis. RESULTS AND CONCLUSION：When we discuss the biological safety of nano-silver on this issue,we should take all these into consideration rather than toxic or nontoxic,such as the shape,particle size,dose,etc. In addition,the nano-silver has strong antibacterial function especially to the common oral pathogen,such as Streptococcus mutans,Lactobacillus oris,Canidia albicans. This function can be used in the prevention and treatment of denture stomatitis. But how to overcome the base oxidation discoloration still remains to be further studied.