抗肿瘤缓释剂在肝癌介入治疗中的应用

背景：肿瘤内直接注入化疗缓释剂为肿瘤的治疗提供了一个新的途径。目的：评价抗肿瘤缓释剂在肝癌中应用,寻找合理的治疗方案。方法：以＂肝癌,植入化疗,缓释植入剂,化学药物为中文关键词;以＂liver cancer,implantation of chemotherapy,sustained release implants,chemicals＂为英文关键词。采用计算机检索1993-01/2010-12相关文章。纳入与有关生物材料与组织工程血管相关的文章;排除重复研究或Meta分析类文章。以29篇文献为主重点进行了讨论抗肿瘤缓释剂在肝癌中应用。结果与结论：植入肝癌中瘤内或肿瘤手术中植入残留灶及可能有微小转移瘤灶区域的化疗缓释植入剂,既提高了肿瘤局部药物浓度及作用时间,同时也降低或避免了全身化疗常见的毒副反应,为肿瘤的化学治疗提供了一条新的给药途径;肿瘤内直接注入化疗缓释剂也为一些失去手术、放疗或不能耐受全身化疗的晚期肿瘤患者减少痛苦和带来新的希望。抗肿瘤缓释剂可作为一种较理想的缓释植入剂应用于肝癌中的化疗药物。

Sustained-release anti-tumor agent in interventional treatment of liver cancer

BACKGROUND：Direct injection of sustained-release chemotherapy provides a new way to tumor treatment.OBJECTIVE：To evaluate the application of sustained-release anti-tumor agents in liver cancer and to find a reasonable treatment.METHODS：A computer based search of relevant articles published 1993-01/2010-12 were retrieved by using the keywords of ＂liver cancer,implantation of chemotherapy,sustained release implants,chemicals＂ in Chinese and English.Repetitive articles and Meta analysis were excluded,and finally 29 articles were included in result analysis.RESULTS AND CONCLUSION：Direct injection of sustained-release chemotherapy improves local tumor drug concentration and reaction time,and reduces or avoids systemic chemotherapy-induced common side effects,providing a new route of administration.Direct injection of sustained-release chemotherapy also relieves the pain of advanced cancer patients,bringing a new hope.Sustained-release anti-tumor agents can be used as an ideal slow-release implant in the chemotherapy drugs used in the treatment of liver cancer.