HLA class II genes in Latvian patients with juvenile rheumatoid arthritis |
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| Authors: | I. Rumba A. Denisova A. Sochnev B. Nilsson C. B. Sanjeevi |
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| Affiliation: | Clinic of Pediatrics, Institute of Immunology, Medical Academy of Latvia, Riga, Latvia;Institute of Immunology, Medical Academy of Latvia, Riga, Latvia;Department of Clinical Immunology. University Hospital, Uppsala;Department of Molecular Medicine, Karolinska Institute, Karolmska Hospital, Stockholm, Sweden |
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| Abstract: | PCR-based HLA genotyping was used to analyze the association of HLA-DR and -DQ genes in 127 juvenile rheumatoid arthritis patients and 111 population-based controls from Latvia. The results show DQA1*03 to be positively associated in overall patients and DRB1*01-DQA1*0101-DQB1*0501 to be negatively associated with JRA in overall patients and in polyarthritis patients compared to controls. These data indicate the immunogenetic heterogeneity in the JRA patients, in the disease subgroups and in different ethnic groups. Rheumatoid factor (RF) was assayed in patients ( n = 119) and controls ( n =98). RF was present in patients (7/119, 6%) compared to controls (5/98, 5%). None of the DQA1, DQB1 alleles, DQ and DR-DQ haplotypes was associated in seropositive patients compared to seropositive controls. DR1-DQ5 (DQA1*0101-B*0501) was decreased in seronegative patients (11/111, 10%) compared to seronegative controls (24/105, 23%), but the difference was not significant after correction of the p value. |
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| Keywords: | HLA-DR HLA-DQ JRA rheumatoid factor genetic susceptibility Latvians |
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