Effects of cyanamide on body weight and brain monoamines and metabolites in rats |
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| Authors: | R Obach A Menargues J Vallès J M Vallès J A García-Sevilla |
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| Affiliation: | 1. College of Geography and Environmental Sciences, Zhejiang Normal University, Jinhua 321004, China;2. Key Laboratory of Watershed Earth Surface Processes and Ecological Security, Zhejiang Normal University, Jinhua 321004, China;1. Department of Chemical Sciences, University of Naples Federico II, Via Cintia 21, I-80126 Naples, Italy;2. Max Planck Institute for Polymer Research, Ackermannweg 10, 55128 Mainz. Germany;3. Université de Strasbourg, Faculté de Chirurgie Dentaire, 8 rue Sainte Elizabeth, 67000 Strasbourg, France;4. Institut National de la Santé et de la Recherche Médicale, Unité mixte de rechere 1121, 1 rue Eugène Boeckel, 67084 Strasbourg Cedex. France |
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| Abstract: | Cyanamide, a disulfiram-like drug used in the treatment of alcoholism, decreased in a dose-dependent manner (2-25 mg/kg) the body weight gain curve in rats, which resulted in a marked decrease of body weight (10-35%). Long-term administration of cyanamide also decreased food intake (6-34%) in a dose-dependent manner (2-25 mg/kg). Both effects of cyanamide were reversible. After the acute and long-term administration (1-12 months) of cyanamide (8-35 mg/kg) the brain concentration of 3-methoxy-4-hydroxyphenylethyleneglycol sulphate (MOPEG-SO4) was also significantly increased (26-46%). Cyanamide, however, had no effects on the brain concentration of noradrenaline, dopamine, 5-hydroxytryptamine, tryptophan and 5-hydroxyindolacetic acid. It is suggested that the loss of weight, the decrease in food intake and the increase in brain MOPEG-SO4 induced by cyanamide reflect possible anorectic properties of the drug. |
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