清热凉血和活血化瘀中药对小鼠实验性银屑病模型的影响

目的：研究丹参、赤芍、当归等10味中药与银屑病治疗有关的作用。方法：利用小鼠银屑病实验模型及PCNA免疫组化方法,分别观察了6味清热凉血药对小鼠阴道上皮有丝分裂和6味活血化瘀药对鼠尾鳞片表皮闰层形成的影响。结果：6味清热凉血中药均能显著抑制小鼠阴道上皮有丝分裂和PCNA表达。6味活血化瘀药中5味均能显著促进表皮分化,其丹以、赤芍又兼具有上述两种,结论：本研究的10味中药对银屑病可能具有治疗作用。

Effect of"heat-clearing and blooding-cooling"and "blooding-activiting and stasis-dissoving" traditional Chinese herbal drugs on experiamental model of psoriasis

To study the potential antipsoriatic effects of 10 Chinese traditional drugs including Radix salviae miltiorrhizal(Danshen), Radix paeoniae rubra(Chishao), Angelicae sinensis(Danggui). The authors observed the effects of 6 kinds of "heat-clearing and blood-cooling" drugs on mitosis of mouse vaginal epithelium and the effects 6 kinds of "blood-activating and stasis-dissolving" drugs on mouse tail epidermal cell differentiation,using the mouse experimental model of the technique of PCNA immunohistohemistry. All of the 6 kinds of "heat-clearing and blood-cooling" drugs significantly inhibited the mitosis of hyperplastic epithelial cells and the expression of PCNA in mouse vaginal epithelia and 5 of the 6 "blood-activating and stasis-dissolving" drugs promoted normal keratinization of parakeratostic epidermal differentiation in mouse tail. In addition, Radix salviae miltiorrhizoe(Danshen) and Radix paeoniae rubra (Chishao)had all the above mentioned effects simultaneously. Conclusion] These results suggeste that each kind of these drugs while used in clinical practice might have antipsoriatic effects.