Cholinesterase activity in the serum and liver of Zucker fat rats and controls

Serum and liver cholinesterase activity was observed to be significantly higher in chow fed Zucker fat rats than in chow fed lean controls. Similarly, serum triglycerides and insulin showed significantly higher levels in the fat rats compared to the controls. In contrast, no significant difference was observed for adipose tissue cholinesterase, serum glucose and cholesterol.Correlation analyses revealed a positive correlation between serum and liver cholinesterase activity when data were combined from both obese and lean rats indicating liver as the possible source of cholinesterase. Serum cholinesterase also correlated positively with triglycerides, body weight and food intake. Food intake also showed a strong positive correlation with serum triglycerides and body weight.