体外培养成骨细胞的研究进展

随着体外细胞培养技术的发展,人们已经从许多动物的颅骨、骨髓基质、骨膜及骨外组织中成功培养出了具有典型成骨细胞特性的细胞,研究表明培养出的成骨细胞具有良好的生物学特性,在不同环境下可以形成骨组织,联合支架的应用,构建组织工程骨,将其植入体内修复骨缺损.现就成骨细胞的来源、分化调控因子、复合移植及中医药方面的研究进展作一综述.

Progressing study in osteoblasts cultured in vitro

With the development of cell culture technology in vitro,people have successfully cultivated osteoblast cells of typical characteristics from a number of animal skull,bone marrow,periosteum and bone tissues;studies have shown that these osteoblasts have good biological characteristics,can create bone tissue in different environments,can apply joint stand for the construction of tissue engineered bone,be implanted in the body to repair bone defects. In this article,the source of osteoblast,regulatory factor,composite graft and Chinese medicine research progress were reviewed.