| 小柴胡汤冲剂治疗子宫内膜异位症的作用机制 |
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| 引用本文： | 郑辉,左连东.小柴胡汤冲剂治疗子宫内膜异位症的作用机制[J].中药新药与临床药理,2005,16(2):90-92. |
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| 作者姓名： | 郑辉 左连东 |
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| 作者单位： | 暨南大学医学院生理学教研室,广州,510632 |
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| 摘 要： | 目的探讨小柴胡汤冲剂治疗大鼠子宫内膜异位症(内异症)的作用机制.方法建立大鼠内异症动物模型,利用免疫组化的方法,观察分析各用药组在位、异位内膜Fas及Caspase-3蛋白的表达.结果小柴胡汤治疗组内异症大鼠异位内膜Fas蛋白、Caspase-3蛋白的表达水平明显高于其在位内膜,而在对照组中的表达却恰恰相反,丹那唑组中两者相差不明显.结论小柴胡汤冲剂治疗大鼠内异症的作用机制可能是通过上调Fas蛋白的表达,促进异位内膜细胞的凋亡而实现的.
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| 关 键 词： | 小柴胡汤冲剂 子宫内膜异位症 大鼠 Fas蛋白 Caspase-3蛋白 |
| 文章编号： | 1003-9783(2005)02-0090-03 |
| 修稿时间： | 2004年9月25日 |
Mechanism of Xiao Chaihu Decoction in the Treatment of Endometriosis |
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| ZHENG Hui,ZUO Liandong.Mechanism of Xiao Chaihu Decoction in the Treatment of Endometriosis[J].Traditional Chinese Drug Research & Clinical Pharmacology,2005,16(2):90-92. |
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| Authors: | ZHENG Hui ZUO Liandong |
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| Abstract: | Objective To explore the mechanism of Xiao Chaihu decoction in t he treatment of endometriosis in rats.Methods The rat model of endometriosis w as established. Fas and Caspase- 3 protein expression in the eutopic endometriu m and eutopic endometrium were observed by immunohistochemical method.Results The protein expression of Fas and Caspase- 3 in ectopic endometrium of Xiao Cha ihu decoction group was higher than that in the eutopic endometrium, while the r esult in the control group was just the opposite. No significant difference was shown in Danazol group. Conclusion The therapeutic mechanism of Xiao Chaihu de coction for endometriosis may be related to the promotion the apoptosis of ectop ic endometrium tissue by increasing Fas protein expression. |
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| Keywords: | Xiao Chaihu decoction Endometriosis Rats Fas protein Caspa se- 3 protein |
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