| 高效液相色谱法测定沙丁胺醇的有关物质 |
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| 引用本文： | 尹菁,石蓓佳.高效液相色谱法测定沙丁胺醇的有关物质[J].海峡药学,2010,22(11):68-70. |
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| 作者姓名： | 尹菁 石蓓佳 |
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| 作者单位： | 江苏省食品药品检验所,南京,210008 |
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| 摘 要： | 目的建立高效液相色谱法测定沙丁胺醇中的有关物质。方法采用C18柱,以庚烷磺酸钠溶液（庚烷磺酸钠2.87g、磷酸二氢钾2.5g,加水溶解并稀释至1000mL,用稀磷酸调节pH值至3.65）-乙腈（78∶22）为流动相,检测波长220nm。结果沙丁胺醇与其降解产物在该色谱条件下能够有效分离。结论方法简便、专属性强,可用于沙丁胺醇中有关物质的测定。
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| 关 键 词： | HPLC法 沙丁胺醇 有关物质 |
Determination of related substance in salbutamol by HPLC |
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| YIN Jing,SHI Bei-jia.Determination of related substance in salbutamol by HPLC[J].Strait Pharmaceutical Journal,2010,22(11):68-70. |
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| Authors: | YIN Jing SHI Bei-jia |
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| Institution: | (Jiangsu Provincial Institute for Food and Drug Control,Nanjing 210008) |
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| Abstract: | OBJECTIVE To establish an HPLC method for determining related substance in Salbutamol.METHODS Using HPLC with C18 column,sodium heptanesulfonate solution（dissolve 2.87g of sodium heptanesulfonate and 2.5g of potassium dihydrogen phosphate in water and dilute to 1000mL with water,adjust to pH3.65 with dilute phosphoric acid）-acetonitrile（78∶22）as the mobile phase and the detection wavelength was 220nm.RESULTS Salbutamol and its related substance can be separated effectively by this method.CONCLUSION The method is simple and reliable.Related substance in Salbutamol can be determined with this method. |
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| Keywords: | HPLC Salbutamol Related Substance |
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