Hormonal changes during experimental hypothalamic obesity in rats |
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| Authors: | E. V. épshtein V. V. Bezrukov |
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| Affiliation: | (1) Radiology Laboratory, Scientific-Research Institute of Endocrinology and Metabolism, Minstry of Public Health of the USSR, Kiev;(2) Physiology Laboratory, Institute of Gerontology, Academy of Medical Sciences of the USSR, Kiev |
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| Abstract: | Conclusions The following changes were observed in rats with experimental hypothalamic obesity: an enhancement in the function of the pancreatic insular apparatus; an increase in hypophyseal STH biosynthesis and secretion; a decrease in hypophyseal thyrotropic function and thyroid gland activity, with disturbances in thyroid hormone metabolism in target tissues; lack of changes or a decrease in adrenal glucocorticoid function; an enhancement of lipogenesis; a decrease in the content of cAMP in a number of organs and tissues.Translated from Problemy éndokrinologii, Vol. 24, No. 1, pp. 55–60, January–February, 1978. |
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