干扰素和核苷酸类对不同HBV基因型慢性乙型肝炎患者的疗效研究 |
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引用本文: | 谢伟贤,黄泽棋,香瑶英,邹敏超,周少雄,肖海萍.干扰素和核苷酸类对不同HBV基因型慢性乙型肝炎患者的疗效研究[J].医学检验与临床,2012(5):42-44. |
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作者姓名: | 谢伟贤 黄泽棋 香瑶英 邹敏超 周少雄 肖海萍 |
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作者单位: | [1]广东省佛山市人民医院检验科,广东佛山528000 [2]广东省佛山市人民医院感染科,广东佛山528000 |
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基金项目: | 佛山市卫生局资助课题(课题编号:2010086) |
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摘 要: | 目的探讨干扰素和核苷酸类对不同HBV基因型慢性乙型肝炎(CHB)患者的疗效。方法对95例CHB患者按基因型和治疗药物的不同分成干扰素B、C型和核苷酸类B、C型共4个组。比较各组治疗前后的血清HBV—DNA含量,丙氨酸氨基转移酶(AIJT),天冬氨酸氨基转移酶(AsT)和总胆红素(TBil)。结果95例HBV—DNA阳性的CHB患者中分为47例B型及48例C型,分剐占49.5%和50.5%。干扰素组25例B型,27例c型;核苷酸类组B型22例,C型21例。在经过12周的早期治疗后,核苷酸类C型组较B型组治疗后的HBV—DNA含量显著性减少(P〈0.01),其余各组问的比较均无统计学意义(P〉0.05)。结论核苷酸类早期治疗C型乙肝病毒感染组效果优于B型组。
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关 键 词: | HBV基因分型 肝功能 乙型肝炎病毒 |
The treatment effect stuey of Interferon and nudeotides on different HBV genotypes patients with chronic hepatitis B |
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Institution: | Xie Weixian, Huang Zeqi, Xiang Yaoying, et al(Foshan city people's hospital, Foshan, 528000) |
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Abstract: | Objective To investigate the interferon and nueleotides on the efficacy of different HBV genotypes in patients with chronic hepatitis B (CHB). Methods 95 eases of CHB patients were divided into 4 groups, interferon type B, interferon type C, nucleotides type B and nucleotides type C, according to genotype and treatment of drug. HBV - DNA, alanine aminotransferase ( ALT), aspartate aminotransferase enzyme (AST) and total bilirubin (TBil) in serum of each group before and after treatment were compared. Results 95 cases of HBV - DNA positive CHB patients were divided into 47 cases of type B and 48 cases of type C accounted for 49.5 % and 50.5 %. Respectively. 25 cases of type B and 27 cases of type C in the interferon group; 22 cases of type B and 21 cases of type C in the nueleofides group. After 12 weeks of early treatment, HBV- DNA content was lower in nucleotides group C than in group B, significant reduction (P 〈 0.01), among other groups showed no statistically significant (P 〉 0.05). Conclusion The early treatment of tvype C in the nuclcotides group is better than type B. |
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Keywords: | HBV genotyping liver function hepatitis B virus |
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