| 灵黄口服液的毒理学安全性评价 |
| |
| 引用本文： | 唐云安,姜幼纯,刘玉清,王国钦,庞定国,李琼英,程薇波,徐培渝,王文冬. 灵黄口服液的毒理学安全性评价[J]. 现代预防医学, 2002, 29(1): 30-32 |
| |
| 作者姓名： | 唐云安 姜幼纯 刘玉清 王国钦 庞定国 李琼英 程薇波 徐培渝 王文冬 |
| |
| 作者单位： | 四川大学华西公共卫生学院,610041 |
| |
| 摘 要： | 目的：了解灵黄口服液的安全性。方法：小鼠急性经口毒性试验，Ames试验，小鼠骨髓嗜多染红细胞微核试验，雄性小鼠精子畸形分析，小鼠睾丸生殖细胞染色体畸变分析，大鼠传统致畸试验等，大鼠90天喂养试验。结果：该口服液急性经口毒性为无毒，在四项遗传毒性试验中均为阴性结果，在传统致畸试验中未见大鼠发育毒性和胚胎毒性，在90天喂养试验中也无异常发现。结论：灵黄口服液安全无毒。
|
| 关 键 词： | 灵黄口服液 安全性 Ames试验 微核试验 毒理学 |
| 文章编号： | 1003-8507(2002)01-0030-03 |
| 修稿时间： | 2001-05-23 |
ESTIMATE ON THE SAFETY TOXICOLOGY OF LINGHUANG ORAL LIQUOR. |
| |
| TANG Yun an,JIANG You chun,LIU Yu qing,et al.. ESTIMATE ON THE SAFETY TOXICOLOGY OF LINGHUANG ORAL LIQUOR.[J]. Modern Preventive Medicine, 2002, 29(1): 30-32 |
| |
| Authors: | TANG Yun an JIANG You chun LIU Yu qing et al. |
| |
| Affiliation: | TANG Yun an,JIANG You chun,LIU Yu qing,et al.West China School of Public Health,Sichuan University,Chengdu,610041,Sichuan Province,China. |
| |
| Abstract: | Objective:To study the safety of the linghuang oral liquor.Methods:The acute toxicity test in mice,Ames test,micronuclei test of bone marrow cell and sperm shape abnormality test and chromosome malformation analysis of testicle reproductive cell in mice,teratogenicity test in rats,90 days feeding test in rats.Results:The linghuang oral liquor has not acute toxicity.All four genotoxicity tests had negative results.The developmental toxicity and embryotoxicity had also not been found in teratogenicity test.Abnormal phenomena had not been found in 90 day feeding test.Conclusion:The linghuang oral liquor is safe to use. |
| |
| Keywords: | Linghuang oral liquor Safety Test |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
