Comprehensive geriatric assessment of elderly highlanders in Qinghai,China, III: Oxidative stress and aging in Tibetan and Han elderly highlanders |
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| Authors: | Ryota Sakamoto Kozo Matsubayashi Yumi Kimura Masayuki Ishine Yasuyuki Kosaka Taizo Wada Chizu Wada Masahiro Nakatsuka Yasuko Ishimoto Mayumi Hirosaki Yoriko Kasahara Akiko Konno Wingling Chen Michiko Fujisawa Kuniaki Otsuka Michiro Nakashima Hongxin Wang Qingxiang Dai Airong Yang Haisheng Qiao Jidong Gao Zhanquan Li Yongshou Zhang Ri‐Li Ge Kiyohito Okumiya |
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| Affiliation: | 1. Research Institute for Humanity and Nature,;2. Center for Southeast Asian Studies,;3. Academic Alpine Club of Kyoto,;4. Kyoto University Graduate School of Medicine Human Brain Research Center,;5. Department of Field Medicine, School of Public Health, Kyoto University,;6. Wildlife Research Center of Kyoto University, Kyoto,;7. Department of Medicine, Tokyo Women's Medical University, Medical Center East, Tokyo, Japan;8. and;9. Affiliated Hospital of Qinghai University,;10. Qinghai Academy Animal and Veterinary Sciences,;11. Haiyan Hospital,;12. Research Center for High Altitude Medicine, Qinghai University, Qinghai, China |
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| Abstract: | Background: Although there are several factors which may contribute to oxidative stress at high altitude, little is known about the association between oxidative stress and aging in the community‐dwelling elderly in the Tibetan Plateau. Methods: Reactive oxygen species (ROS) and comprehensive geriatric functions were examined among 235 community‐dwelling elderly subjects aged 60 years or more (146 Hans and 89 Tibetans). As a marker of ROS, the levels of reactive oxygen metabolites (ROM) were measured using the d‐ROM test. Results: The rate of dependence of basic activities of daily living (basic ADL) among Tibetan elderly highlanders was significantly higher than that among Han elderly highlanders. The d‐ROM level was higher among the Tibetan elderly than those among the Han elderly (Tibetan 465.6 ± 97.9 Carr U, Han 415.3 ± 72.0 Carr U, P = 0.003). The ROM level was higher among women than those among men. Stepwise multiple regression analysis showed that being Tibetan, female, and oxygen saturation were independent predictors of increasing d‐ROM level (Tibetan β, 0.241; female β, 0.206; oxygen saturation β, 0.218). The high levels of ROM (d‐ROM >500 Carr U) were significantly associated with dependence of basic ADL after adjustment for age, sex and ethnicity (odds ratio = 2.51, P = 0.028). Conclusion: The findings of this study imply the possibility that ROS is higher among Tibetan elderly highlanders than that of Han, which related to the geriatric items. Further studies are needed to show the impact of oxidative stress on the aging of highlanders. |
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| Keywords: | aging elderly highlanders oxidative stress reactive oxygen species |
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