Compared staining of the phospholipase A2 receptor in the glomeruli of Chinese adults and children with idiopathic membranous nephropathy |
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Authors: | Dan Zhang Ying Wu Chong Zhang Wenzhu Zhang Jun Zou Gengru Jiang |
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Institution: | 1. Department of Nephrology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Kong Jiang Road, 1665, 200092, Shanghai, China;2. Department of Nephrology and Rheumatology, Children''s Hospital of Shanghai, Shanghai Jiao Tong University, Shanghai, China;3. Department of Histopathology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China |
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Abstract: | BackgroundThe identification of the M-type phospholipase A2 receptor (PLA2R) is a breakthrough recognized as a major target for adults with idiopathic membranous nephropathy (IMN). However, the role PLA2R played in pediatric patients with IMN, particularly in Chinese, has yet to be determined.MethodsThis retrospective study included 187 adult patients and 38 pediatric patients aged 17 years or younger with biopsy proved IMN. The pediatric cohort consisted of 27 children aged from 1 to 12 years and 11 children aged from 13 to 17. Glomerular expression of PLA2R was analyzed in stored, formalin-fixed, paraffin-embedded kidney biopsy sections.ResultsPLA2R staining in glomerular deposits was observed in 82.7% and 42.1% of adult and pediatric patients with IMN, respectively. The PLA2R-positive staining patients with IMN presented with more severe clinical features than PLA2R-negative staining patients in both adult and pediatric cohorts. When compared to the young children patients with IMN, the adolescents exhibited a higher positive rate of PLA2R staining (81.8% versus 25.9%), similar to the adult patients.ConclusionThe clinical features and prevalence of PLA2R positive staining in adolescent patients with IMN were similar to adult patients, suggesting that they probably have a close etiology and pathogenesis. However, most of the young children patients with IMN were PLA2R negative staining, suggesting a different underlying etiology. |
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Keywords: | PLA2R Idiopathic membranous nephropathy Adolescent Pediatric |
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