家兔心肌缺血及再灌流对红细胞变形能力的损伤及其防治的实验研究

本文以家兔为对象,利用激光衍射法研究了在结扎冠状动脉左室枝后及放开结扎重新供血造成再灌流时红细胞变形能力的改变情况。结果表明:再灌流对红细胞变形能力的损伤程度比单纯缺血严重得多,这些改变可以引起并加重心肌微循环障碍,导致心肌细胞的进一步损伤,再灌流前给予山莨菪碱和樟柳碱均可以有效地改善红细胞的变形能力。结果提示对心肌梗塞患者及时给予山茛菪碱或樟柳碱可能有助于防止再灌流对红细胞变形能力的损伤。

The experimental study of injury on erythrocyte deformability caused by myocardial ischemia and reperfusion and its protection in rabbits

In the present study, forty New Zealand white rabbits (both sexes, 2.0-2.5kg) were used to study the changes of red blood cell deformability when the left thoracotomy of the rabbits was performed to identify and occlude the circumflex coronary artery for a time period and then released to allow reperfusion. We used the laser diffraction methods to study the red blood cell deformability. The results were as follows: red blood cell deformability were decreased more significantly in reperfusion group than in ischemia group, these results could lead to the microcirculation disturbance and further ischemia and cell death, Anisodamine and Anisodine when they were given before reperfusion could prevent the reduction of red blood cell deformability. These results suggest that reperfusion can cause more damage to the red blood cell deformability. When Anisodamine and Anisodine were given to the myocardial infarction patients timely tmight have contributed to prevent the damage by reperfusion on the red blood cell deformabilty.