低功率超声栓塞肿瘤新生血管治疗肿瘤的临床研究

目的探讨低功率超声辐射血管内微泡剂对恶性肿瘤血管的临床生物疗效.方法 83例恶性肿瘤患者,外周静脉注入CO2微泡剂,以低功率低频率超声(0.5 W)经皮辐射肿瘤局部,每周2～3次,每例病人治疗3～6次.结果超声组50例疗效:治疗后病变缩小达50%以上,呈部分缓解为13例,有效率占总数的26%;稳定为27例,占总数的54%;进展为4例,占总数的8%;生活质量评分改善为28例,占总数的56%;治疗后出现肝功能等指标升高的4例,占总数的8%,均为与化疗联合治疗者;癌痛不适改善为35例,占总数的70%;治疗后局部一般未发现明显损伤;肝脏肿瘤局部治疗后,肝酶ALT、AST未见明显升高.结论低功率超声辐射血管内微泡剂可以成为局部治疗恶性肿瘤的一种无创的新方法.

Clinical study on formation of angiogenesis embolization in tumor by low power ultrasound

Objective To explore the clinical and biological effects induced with low power ultrasound radiating CO_2 micro-bubble into the vessel. Methods Through peripheral vein injected CO_2 micro-bubble agent, tumor was radiated locally with low power ultrasound (0.5 W) on skin surface 2-3 times weekly, 3-6 times for every patient in total of 83 cases with malignance including those in wall of thorax and abdomen or in cavity of antinode. Results The cases got regression above 50% in 13 cases (26%), steady in 27 cases (54%), progression in 4 cases (8%), improvement in the score of quality of life in 28 cases (56%); post-treatment 4 cases (8%) emerge hepatic function in elevated, which were cases that associated with chemical therapy; amelioration of cancer ache in 35 cases (70%). The marked damage was not found after treated in those patients. Serum liver enzymes ALT and AST were not found abnormal heightening change after local treatment on hepatic malignance. Conclusion It will become a new method without damage for treating malignant tumor with low power ultrasound radiating CO_2 micro-bubble into the vessel.