| 一种白僵菌代谢产物提取物对小鼠左旋多巴奔跑实验的影响 |
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| 引用本文： | 周兰兰,明亮,马传庚,程燕. 一种白僵菌代谢产物提取物对小鼠左旋多巴奔跑实验的影响[J]. 安徽医科大学学报, 2004, 39(4): 262-263 |
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| 作者姓名： | 周兰兰 明亮 马传庚 程燕 |
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| 作者单位： | 安徽医科大学药理学教研室,合肥,230032;安徽医科大学药理学教研室,合肥,230032;安徽医科大学药理学教研室,合肥,230032;安徽医科大学药理学教研室,合肥,230032 |
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| 基金项目： | 安徽省自然科学基金，安徽省教育厅科研项目 |
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| 摘 要： | 目的研究一种白僵菌代谢产物提取物(BCEF)对左旋多巴奔跑实验的影响.方法采用左旋多巴奔跑实验研究BCEF抗实验性抑郁作用及可能的作用机制;采用荧光分光光度计法检测BCEF对模型动物脑组织多巴胺(DA)含量的影响.结果 BCEF组小鼠出现活动增多比率为10%,而阳性对照组小鼠表现明显奔跑、跳跃(比率为90%),两组差异有显著性;BCEF 25、100 mg/kg剂量组对模型小鼠脑组织DA的含量有不同程度的提高.阳性对照组20 mg/kg对模型小鼠脑组织的DA含量有显著的提高.结论 BCEF对左旋多巴奔跑实验小鼠活动无明显的增强作用.
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| 关 键 词： | 孢子 真菌 左旋多巴 多巴胺 |
| 文章编号： | 1000-1492(2004)04-0262-02 |
| 修稿时间： | 2003-12-23 |
Effects of bioactive compounds from entomogenousfungi on L-dopa induced running response test |
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| Zhou lanlan,Ming Liang,Ma Chuangeng et al. Effects of bioactive compounds from entomogenousfungi on L-dopa induced running response test[J]. Acta Universitis Medicinalis Anhui, 2004, 39(4): 262-263 |
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| Authors: | Zhou lanlan Ming Liang Ma Chuangeng et al |
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| Abstract: | Objective To study the effects of bioactive compounds from entomogenous fungi(BCEF) on L-dopa induced running response test. Methods L-dopa induced running response test was used to examine the antidepression effects of BCEF and its mechanism. Spectrofluorometer and UV spectrophotometer analysis technique were used to detect the content of dopamine (DA). Results The running number of mouse in BCEF (10%) was much lower than the number in MOC(90%). BCEF(25,100 mg/kg) raised the content of DA in different degree. MOC also raised the content of DA efficiently. Conclusion The results suggest that BCEF has no effect on L-dopa induced running response test. |
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| Keywords: | spores fungal levodopa dopamine |
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