酒精性肝病治疗方法进展

酒精性肝病包括急性酒精性肝炎和酒精性肝硬化.戒酒一直是治疗所有酒精性肝病的基础.近年来,关于乙醇引起肝损伤机制的研究,提出了酒精性肝病治疗发展的前景.本文作者回顾近期资料关于急性酒精性肝损伤治疗的效果,包括营养治疗、皮质激素类、抗炎因子、抗氧化剂和一些直接抗纤维化过程的要素,如秋水仙碱和抗氧化物质.治疗方法包括直接改变肝损伤和修复进程,但无可持续改善酒精性肝损害的疗法.因此,肝移植仍是因慢性酒精性肝损伤致肝功能衰竭病人的最终选择.

Current management of alcoholic liver disease

Alcoholic liver disease includes acute alcoholic hepatitis and alcoholic cirrhosis.Abstinence remains the cornerstone of management of all forms of alcoholic liver disease.Recent research,which has elucidated the mechanisms of alcohol-induced liver injury,offers the prospect of advances in the management of alcoholic liver disease.We review the most recent data on the efficacy of treatment of acute alcoholic injury,including nutritional support,corticosteroids,anti-inflammatory agents and antioxidants,and agents that are directed against the progression to fibrosis,such as colchicines and antioxidants. Although these therapies offer a tantalizing glimpse into future that may include therapies that directly alter the process of injury and repair in the liver,none has been shown consistently to improve the course of alcoholic liver damage.Consequently,liver transplantation remains an ultimate option for selected patients with liver failure due to chronic alcoholic liver damage.