Effect of prostacyclin (PGI2) and a prostaglandin analogue BW 245C on galactosamine-induced hepatic necrosis |
| |
| Authors: | Y Noda R D Hughes R Williams |
| |
| Affiliation: | 1. Division of Gastroenterology, University of California San Diego, La Jolla, California;2. Dr Henry D. Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, New York;3. Robarts Clinical Trials, Robarts Research Institute, Department of Medicine, Western University, London, Ontario, Canada;1. Laboratoire GEOsciences Paris-Sud (GEOPS), UMR 8148, CNRS-Université de Paris-Sud, Université Paris-Saclay, Bâtiment 504, 91405, Orsay Cedex, France;2. Laboratoire des Sciences du Climat et de l’Environnement, LSCE/IPSL, CEA-CNRS-UVSQ, Université Paris-Saclay, F-91191, Gif-sur-Yvette, France;3. Royal Netherlands Institute for Sea Research (NIOZ) and Utrecht University, Den Burg, Netherlands;4. Ghent University, Dept. of Geology, Ghent, Belgium;5. Universität Heidelberg, Im Neuenheimer Feld 229, 69120, Heidelberg, Germany;6. EPOC-CNRS, Université de Bordeaux, Allée Geoffroy Saint Hilaire, 33615, Pessac Cedex, France;7. M2C, Université de Rouen, 76821, Mont-Saint-Aignan Cedex, France;1. School of Allied Health Science and Practice, University of Adelaide, Adelaide, South Australia, Australia;2. College of Medicine and Public Health, Flinders University, Adelaide, South Australia, Australia;3. School of Social Sciences, University of Adelaide, Adelaide, South Australia, Australia;4. Fay Gale Centre for Research on Gender, University of Adelaide, South Australia, Australia;5. School of Psychology, University of Adelaide, Adelaide, South Australia, Australia;6. Torrens University, Adelaide, South Australia, Australia;1. College of Materials Environment Engineering, Hangzhou Dianzi University, Hangzhou 310018, PR China;2. College of Science, Hangzhou Dianzi University, Hangzhou 310018, PR China |
| |
| Abstract: | The reported cytoprotective effects of prostaglandins against noxious stimuli in the liver was the basis for the present investigations of the effects of prostacyclin (PGI2) and a prostaglandin analogue (BW 245C) in an animal model of severe liver failure. Rats were given galactosamine at two dose levels and the prostaglandins were given in repeated doses from 0 to 6 h during the development of the liver damage or in another group from 24 to 30 h at the time of maximal liver injury. For PGI2 significant cytoprotection was found as assessed by a reduction in blood Normotest at 24, 48 and 72 h (P less than 0.05) and the plasma level of aspartate aminotransferase at 24 and 48 h (P less than 0.02) and the lysosomal markers N-acetyl-beta-glucosaminidase at 24, 48 and 72 h (P less than 0.001) and cathepsin D at 48 h (P less than 0.005) as compared to appropriate controls. Early administration of PGI2 reduced the mortality rate from 63% in the control group to 0% (P less than 0.01) in the treated group, but no significant effects were found when either compound was given later in the 24-h to 30-h period. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
