脂蛋白(a)、纤维蛋白原在腔隙性脑梗死中的价值研究

目的探讨脂蛋白(a)LP(a)]在腔隙性脑梗死(LI)发生中的作用;血清LP(a)水平在腔隙性脑梗死患者合并高血压或糖尿病时的变化;LP(a)和纤维蛋白原(FIB)在腔隙性脑梗死发生发展中的相关性及临床意义。方法选择90例腔隙性脑硬死患者分为三组单纯腔隙性脑梗死组、合并高血压组、合并糖尿病组,23例健康者作为正常对照,探讨LP(a)水平的变化;选择40例腔隙性脑梗死患者,分析LP(a)与纤维蛋白原的相关性。结果LP(a)水平在腔隙性脑梗死患者与正常对照组间有显著差异性(P≤0.05);不同病例组间LP(a)水平无显著差异性;LP(a)和纤维蛋白原在腔隙性脑梗死患者的发病中无相关性。结论LP(a)是腔隙性脑梗死的危险因素,与高血压、糖尿病无关;在腔隙性脑梗死的发生发展中,LP(a)与纤维蛋白原有各自的主要参与机制。

Value of lipoprotein(a) and fibrinogen in lacunar infarction

Objective:To investigate the role of serum lipoprotein(a)LP(a)] in patients with lacunar infarction,and the changes of serum lipoprotein(a) in patients with lacunar infarction combined with hypertention or diabetes mellitus,and the relation between lipoprotein(a) and fibrinogen(FIB) and their clinical significance.Methods:Ninety patients with lacunar infarction were selected and determined lipoprotein(a).They are divided into three groups:lacunar infarction group,combined with hypertention group,combined with diabetes mellitus group.Twenty-three health persons as control group.Fourty patients with lacunar infarction were selected and to analyse the relation between lipoprotein(a) and fibrinogen.Results:In the patients,lipoprotein(a) were higher than those in the control group(P≤0.05).There was no marked difference among patient groups.It was negative relation between lipoprotein(a) and fibrinogen in lacunar infarction patients.Conclusion:Lipoprotein(a) is a risk factor for lacunar infarction and independent of hypertention and diabetes mellitus.Lipoprotein(a) and fibrinogen have there own main mechanism in the occurrence and development of lacunar infarction.