In vitro activity of LY333328, an investigational glycopeptide antibiotic, against enterococci and staphylococci. |
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| Authors: | R S Schwalbe A C McIntosh S Qaiyumi J A Johnson R J Johnson K M Furness W J Holloway L Steele-Moore |
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| Abstract: | The in vitro activities of LY333328 were compared with those of vancomycin, teicoplanin, and quinupristin-dalfopristin (Synercid) against 219 strains of enterococci and staphylococci, including vancomycin-resistant enterococci and methicillin-resistant Staphylococcus aureus. MICs and MBCs were determined by a microtiter dilution protocol. LY333328 demonstrated superior activity against vancomycin-resistant enterococci and was the only antibiotic which was bactericidal. Its potency was comparable or superior to those of other antibiotics tested against methicillin-resistant staphylococci. |
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