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几种活血中药对ApoE缺陷小鼠动脉粥样硬化斑块的影响
引用本文:文川,徐浩,黄启福,陈可冀,李萍,盛巡.几种活血中药对ApoE缺陷小鼠动脉粥样硬化斑块的影响[J].中国病理生理杂志,2005,21(5):864-867.
作者姓名:文川  徐浩  黄启福  陈可冀  李萍  盛巡
作者单位:1北京中医药大学, 北京 10002;2中国中医研究院西苑医院, 北京 100091;3北京中医医院中药研究所, 北京 100010
基金项目:国家自然科学基金资助课题(No.30271662)
摘    要:目的:从形态学角度观察几种常用活血中药:丹参、赤芍、川芎、三七、桃仁和酒大黄对ApoE基因缺陷小鼠动脉粥样硬化斑块稳定性的影响。 方法: 观察主动脉根部,取4个切面,HE染色和MASSON染色,利用计算机图像分析仪测量斑块面积、血管横截面积、脂质中心面积、胶原面积,最小纤维帽厚度,计算校正斑块面积(斑块面积/血管横截面积)及脂质中心面积占斑块面积百分比,校正胶原面积(胶原面积/血管横截面积)。 结果: 与模型组比较:酒大黄组可显著降低经血管横截面积校正以后的斑块面积;丹参组、桃仁组和酒大黄组可明显减少脂质中心面积及脂质中心在AS斑块中的百分比(P<0.05,P<0.01);三七组亦可明显减少脂质中心在AS斑块中的百分比(P<0.05)。赤芍组、川芎组、桃仁组和酒大黄组的最小纤维帽较厚(P<0.05,P<0.01)。 结论: 提示上述活血中药可能干预ApoE缺陷小鼠动脉粥样硬化斑块的形态结构,稳定斑块,其作用与上述各味中药活血化瘀功效强弱并不完全一致。

关 键 词:动脉粥样硬化  易损斑块  活血化瘀  
文章编号:1000-4718(2005)05-0864-04
收稿时间:2004-12-5
修稿时间:2005-1-19

Effects of herbs of activation blood on atherosclerotic plaque morphology in ApoE gene-deficient mice
WEN Chuan,XU Hao,HUANG Qi-fu,CHEN Ke-ji,LI Ping,SHENG Xun.Effects of herbs of activation blood on atherosclerotic plaque morphology in ApoE gene-deficient mice[J].Chinese Journal of Pathophysiology,2005,21(5):864-867.
Authors:WEN Chuan  XU Hao  HUANG Qi-fu  CHEN Ke-ji  LI Ping  SHENG Xun
Institution:1Departmant of Pathology, Beijing University of Traditional Chinese Medicine, Beijing 100029, China;2Xiyuan Hospital, China Academy of Traditional Chinese Medicine, Beijing 100091, China;3Beijing Institute of Traditional Chinese Medicine, Beijing 100010, China
Abstract:AIM: To observe the effects of six common traditional Chinese herbs of activating blood, paeoniae rubra radix, salviae miltiorrhizae radix, ligustici, rhizome, notoginseng radix, pruni persicae semen and wine staemed radix et rhizome, on atherosclerotic plaque structure and stabilization in ApoE gene-deficient mice. METHODS: Four sections of the aortic root were choosen and stained with hematoxylin and masson. All sections were measured with Image-Pro Plus Version 4.5.1 (IPP) software. RESULTS: Compared with the model group, plaque area corrected by cross-sectional vessel wall area reduced significantly in salviae miltirrhizae radix treatment group, lipid core area reduced in paeoniae rubra radix group, pruni persicae semen and wine steamed radix et rhizome treatment group, minimum thickness of fibrous cap became thicker significantly in salviae miltiorrhizae radix, ligustici, rhizome, pruni persicae semen and wine steamed radix et rhizome treatment group. CONCLUSION: These Chinese herbs may stabilize the atherosclerotic plaques in ApoE gene-deficient mice by interfering their structure, but their effects do not parallel with their activating blood efficacy in traditional Chinese medicine.
Keywords:Atherosclerosis  Vulnerable plaque  Activating blood circulation and remove stasis
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