| 反复性脑缺血致大鼠大脑皮质损伤与cAMP、SOD及MDA含量的变化 |
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| 引用本文： | 曹仁存,郑彩梅,欧阳尧. 反复性脑缺血致大鼠大脑皮质损伤与cAMP、SOD及MDA含量的变化[J]. 西南国防医药, 1995, 0(Z1) |
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| 作者姓名： | 曹仁存 郑彩梅 欧阳尧 |
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| 作者单位： | 成都军区总医院神经内科(曹仁存)，第三军医大学西南医院神经内科(郑彩梅)，成都军区总医院神经内科(欧阳尧) |
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| 摘 要： | 本实验动态对比观察单次性15mim和反复性3×5min大鼠全脑缺血/再灌流,大脑皮质cAMP、SOD和MDA含量的变化及相应的病理改变、发现反复性脑缺血及再灌流早期cAMP含量明显增高,SOD活性显著降低,MDA则延迟性持续显著增高;反复性缺血组皮质神经元损害显著重于单次缺血组。结果提示cAMP和自由基均可能参与了反复性脑缺血神经元损害的病生机制。
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| 关 键 词： | 反复性脑缺血 cAMP 自由基 大鼠 |
Changes of CAMP,SOD and MDA in the rat cerebrai cortex following repeated ischemic insults |
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| Cao Rencun,Zhen Caimei and Ou Yanyou. Departent of neurology Chengdu Army General Hospital,Chengdu. Changes of CAMP,SOD and MDA in the rat cerebrai cortex following repeated ischemic insults[J]. Medical Journal of National Defending forces in Southwest China, 1995, 0(Z1) |
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| Authors: | Cao Rencun Zhen Caimei Ou Yanyou. Departent of neurology Chengdu Army General Hospital Chengdu |
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| Affiliation: | Cao Rencun,Zhen Caimei and Ou Yanyou. Departent of neurology Chengdu Army General Hospital,Chengdu 610083 |
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| Abstract: | The cortical cyclic AMP (CAMP) .superoxide (SOD), malondialdehyde (MO A) contents and pathological chandes were obsered during ischemia and reperfusion period in rats either with a single 15 - minute ischemia or with repeated three - 5 minute ischemia. It was found that the cortical cAMP contents in the repeated ischemic group were singnificanty higher,the level of SOD activity decr-dased significantly during ischemia period and the early reperfusion, whereas the contents of MDA showed a delayed and long - lasting increase. Meanwhile, the cortical damage in the group of repeated cerebral ischemia was more severe than single ischemic insult gyoup. The present results swggested that the cAMP and free redical may participate in the pathogenesis of repeated cerebral ischemic damage |
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| Keywords: | repaled cerebral ischemia cyclic AMP free radical rat |
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