New macrolides and furan carboxylic acid derivative from the sponge-derived fungus Cladosporium herbarum |
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| Authors: | Jadulco R Proksch P Wray V Sudarsono Berg A Gräfe U |
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| Institution: | Institut für Pharmazeutische Biologie, Heinrich-Heine-Universit?t Düsseldorf, Universit?tsststrasse 1, D-40225 Düsseldorf, Germany. |
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| Abstract: | Bioassay-guided fractionation of organic extracts of Cladosporium herbarum, isolated from the marine sponge Callyspongia aerizusa, yielded two new macrolide metabolites: pandangolide 3 and 4 (1 and 2) and the known fungal metabolites pandangolide 2 (3), cladospolide B (4), and iso-cladospolide B (5). Also isolated were the antimicrobially active (against Bacillus subtilis and Staphylococcus aureus) furan carboxylic acids: Sumiki's acid (6) and its new derivative, acetyl Sumiki's acid (7). All structures were elucidated by spectroscopic methods. |
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